Which TB drugs are safe in pregnancy?

Which TB drugs are safe in pregnancy?

All 4 first line drugs [isoniazid, rifampicin (rifampin), ethambutol and pyrazinamide] have an excellent safety record in pregnancy and are not associated with human fetal malformations.

Which TB drugs are bactericidal?

In this context, a distinction is drawn between agents that will kill bacilli in vitro (bactericidal agents) and those that will sterilize lesions in vivo. The most effective agents for the destruction of tubercle bacilli in the three categories described above are, respectively, isoniazid, pyrazinamide and rifampicin.

Is rifampin safe in pregnancy?

Hemorrhagic disease of the newborn has been described following the use of rifampin in the mother (141 ). However, extensive experience with the use of rifampin to treat TB in pregnant women suggests it is safe in most circumstances.

Why is pyrazinamide contraindicated in pregnancy?

In most cases, pyrazinamide (PZA) is not recommended to be used because its effect on the fetus is unknown. HIV Infection – HIV-infected pregnant women who are suspected of having TB disease should be treated without delay. TB treatment regimens for HIV-infected pregnant women should include a rifamycin.

Is ethambutol bacteriostatic or bactericidal?

Ethambutol is bacteriostatic at low doses but is used in TB treatment at higher bactericidal doses. Rifampicin is bactericidal and has a sterilizing effect.

What is AT injection pregnancy?

Tetanus vaccine is given to pregnant women in order to prevent neonatal tetanus due to unclean instruments used to cut the umbilical cord. Everyone needs protection from tetanus. If you have not had a booster shot in 10 years or more, you should receive a tetanus shot.

Is INH bacteriostatic or bactericidal?

The bactericidal activity of isoniazid was strongest. The bactericidal activity of isoniazid and streptomycin was most marked in the log phase.

Which TB drug is contraindicated in pregnancy?

The following antituberculosis drugs are contraindicated in pregnant women: Streptomycin. Kanamycin. Amikacin.

Which drug is bactericidal?

Bactericidal antibiotics that inhibit cell wall synthesis: the beta-lactam antibiotics (penicillin derivatives (penams), cephalosporins (cephems), monobactams, and carbapenems) and vancomycin. Also bactericidal are daptomycin, fluoroquinolones, metronidazole, nitrofurantoin, co-trimoxazole, telithromycin.

Why is rifampin bactericidal?

Rifampicin also called rifampin, inhibits bacterial RNA polymerase and is effective as a bactericidal agent against different pathogens, particularly mycobacteria.

What is Tetvac injection?

Tetvac Injection is a Injection manufactured by SERUM INSTITUTE OF INDIA. It is commonly used for the diagnosis or treatment of tetanus, locked jaw, tightening of body muscles . It has some side effects such as Fever,Allergic reactions,Continued pain in upper arm,Body ache.

Are there any antituberculosis drugs for pregnant women?

The following antituberculosis drugs are contraindicated in pregnant women: Streptomycin. Kanamycin. Amikacin. Capreomycin. Fluoroquinolones.

Which is the best treatment for TB during pregnancy?

TB Treatment & Pregnancy. The preferred initial treatment regimen is INH, rifampin (RIF), and ethambutol (EMB) daily for 2 months, followed by INH and RIF daily, or twice weekly for 7 months (for a total of 9 months of treatment). Streptomycin should not be used because it has been shown to have harmful effects on the fetus. Pyrazinamide (PZA)…

Can a pregnant woman take PZA for TB?

Although the routine use of PZA during pregnancy is not recommended in the United States, the benefits of a TB treatment regimen that includes PZA for HIV-infected pregnant women may outweigh the undetermined potential risks to the fetus. The following antituberculosis drugs are contraindicated in pregnant women:

Can a pregnant woman take rifamycin for TB?

TB treatment regimens for HIV-infected pregnant women should include a rifamycin. Although the routine use of PZA during pregnancy is not recommended in the United States, the benefits of a TB treatment regimen that includes PZA for HIV-infected pregnant women may outweigh the undetermined potential risks to the fetus.