What is the difference between ICAM and VCAM?
ICAM (CD-54) is a ligand for the cell adhesion receptor LFA-1, shown to be important in immune stimulation that is upgraded in inflammatory cutaneous disorders. VCAM (CD-106) is an adhesion molecule normally found in stimulated endothelium, that plays a critical role in the migration of leukocytes.
What does VCAM-1 stand for?
Abstract. Objectives: Vascular cell adhesion molecule-1 (VCAM-1) is a cell surface adhesion molecule involved in the recruitment of leukocytes to endothelial cells on arterial walls during the pathogenesis of atherosclerosis.
What is VCAM in immunology?
Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene. VCAM-1 functions as a cell adhesion molecule.
What is ICAM in immunology?
ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene. This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system.
What does ICAM mean?
ICAM
| Acronym | Definition |
|---|---|
| ICAM | Integrated Computer Aided Manufacturing |
| ICAM | Integrated Computer-Aided Manufacturing |
| ICAM | Improved Chemical Agent Monitor |
| ICAM | Interdisciplinary Center for Applied Mathematics |
What does P selectin do?
P-selectin mediates the rolling of blood cells on the surface of the endothelium and initiates the attachment of leukocytes circulating in the blood to platelets, endothelial cells,and other leukocytes at sites of tissue injury and inflammation.
Is VCAM-1 an integrin?
VCAM-1 is a ligand for the α4β1 integrin (VLA-4) and binds weakly to α4β7 (102,205–207). A single VCAM-1 gene gives rise through alternative splicing to distinct isoforms (204, 208–211). The major form of VCAM-1 in humans contains seven Ig domains of which domains 1–3 are homologous to domains 4–6 (204).
Is VCAM-1 a cytokine?
Vascular Cell Adhesion Molecule 1 (VCAM-1, CD106) VCAM-1 is a cytokine-inducible endothelial CAM that can be expressed in two alternatively spliced versions, existing primarily in a seven-domain form rather than the rarer six-domain form.
What is Credential and Access Management?
Identity, credential, and access management (ICAM) comprises the tools, policies and systems that allow an organization to manage, monitor and secure access to protected resources.
What is leukocyte rolling?
Leukocyte rolling describes the low affinity adhesive interaction between leukocytes and the vascular endothelium whereby the force of blood flow induces a rotational motion (i.e., rolling) of the leukocyte along the vascular wall.
Which is the best description of ICAM-1?
DOI: 10.1002/JLB.2MR0220-549R Abstract ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation.
What is the function of the VCAM-1 gene?
VCAM-1 functions as a cell adhesion molecule . ICAM-1 is a member of the immunoglobulin superfamily, the superfamily of proteins including antibodies and T-cell receptors. The VCAM-1 gene contains six or seven immunoglobulin domains, and is expressed on both large and small blood vessels only after the endothelial cells are stimulated by cytokines.
What is the role of ICAM-1 in intestinal inflammation?
Relative roles of ICAM-1 and VCAM-1 in the pathogenesis of experimental radiation-induced intestinal inflammation ICAM-1 plays a key role in leukocyte recruitment at early time points after abdominal irradiation, whereas VCAM-1 is the main molecular determinant of leukocyte recruitment at late time points.
Where can VCAM-1 be found in the body?
VCAM-1 is also expressed in several nonvascular cell types, including populations of dendritic cells found in lymph nodes and skin, bone marrow stromal cells, and synovial cells in inflammed joints (219,220).