What is P19 stem cells?
P19 cells is an embryonic carcinoma cell line derived from an embryo-derived teratocarcinoma in mice. The cell line is pluripotent and can differentiate into cell types of all three germ layers. Indeed, exposing aggregated P19 cells to dimethyl sulfoxide (DMSO) induces differentiation into cardiac and skeletal muscle.
What is P19 cancer?
Abstract. P19 cells are a line of pluripotent embryonal carcinoma able to grow continuously in serum-supplemented media. The differentiation of these cells can be controlled by nontoxic drugs.
What are embryonal carcinoma cells?
Embryonal carcinoma (EC) cells are the stem cells of teratocarcinomas, and the malignant counterparts of embryonic stem (ES) cells derived from the inner cell mass of blastocyst-stage embryos, whether human or mouse.
What causes embryonal cell carcinoma?
The most accepted theory on the development of germ cell tumors involves an initiating event that causes fetal gonocytes to undergo abnormal cell division. As with other germ cell tumors, with the exception of spermatocytic seminoma, embryonal carcinomas are believed to originate from intratubular malignant germ cells.
Why is it called embryonal carcinoma?
Yolk sac carcinoma: These tumors are so named because their cells look like the yolk sac of an early human embryo. Other names for this cancer include yolk sac tumor, endodermal sinus tumor, infantile embryonal carcinoma, or orchidoblastoma.
Are Germinomas hereditary?
Although familial intracranial germ cell tumor is very rare, the fact that the parents of patients in previous and our reports had no abnormalities of possible hereditary origin suggests that these familial germ cell tumors might be an autosomal recessive disorder, as reported in the analysis of familial testicular …
What is an embryonal cell?
(em-BRY-uh-nul TOO-mer) A mass of rapidly growing cells that begins in embryonic (fetal) tissue. Embryonal tumors may be benign or malignant, and include neuroblastomas and Wilms tumors.
Is embryonal carcinoma painful?
Conclusion. Embryonal cell carcinoma is one of the most common testicular malignancies. Testicular carcinomas most commonly occur in 20- to 30-year-old men. Some common symptoms of embryonal cell carcinoma include swelling and a painful, palpable mass located on the testis.
What is the most common tumor of testis?
The most common type of testis cancer is a germ cell tumor. There are two main types of GCT: seminoma and nonseminomatous germ cell tumors (NSGCT). Both seminoma and NSGCT occur at about the same rate, and men can have seminoma, NSGCT or a combination of both.
Are Germinomas malignant?
Germinoma. This is a slow-growing germ cell tumor. It is cancer (malignant). The tumor is called dysgerminoma when it grows in the ovaries.