What is HER2/neu amplified?
Her-2/neu is a member of the epidermal growth factor receptor family that has been found to be overexpressed or amplified in approximately 20-30% of breast cancers.
Is HER2/neu the same as HER2?
The proteins they make can also be tested. The HER2 gene makes HER2 proteins (also sometimes referred to as HER2/neu proteins). HER2 proteins are receptors on breast cells.
What is Neu mean?
NEU
| Acronym | Definition |
|---|---|
| NEU | Neutral |
| NEU | Near East University (North Cyprus, Turkey) |
| NEU | Northeast University (China) |
| NEU | Nunavut Employees Union (Canada) |
How is HER2 gene amplification used in cancer treatment?
HER2gene amplification analysis is offered specifically as a prognostic and predictive molecular marker for invasive breast carcinoma and as an adjunctive test in the manage- ment of patients with advanced breast carcinoma for whom therapy with trastuzumab is contemplated.
What kind of protein is HER2 / Neu?
HER2/neu. HER2/neu (also known as ErbB-2) is a member of the epidermal growth factor receptor (EGFR) family, also known as the ErbB protein family that includes EGFR, HER2, HER3, and HER4.
What does HER2 mean for triple negative breast cancer?
If the IHC result is 2+, the HER2 status of the tumor is not clear and is called “equivocal.” This means that the HER2 status needs to be tested with FISH to clarify the result. Triple-negative breast tumors don’t have too much HER2 and also don’t have estrogen or progesterone receptors. They are HER2-, ER-, and PR-negative.
How is overexpression of HER2 / Neu used in medicine?
Overexpression or amplification has been shown to correlate with a poor prognosis; however, the studies differ with regard to the method of detection used and the interpretation of results. HER2/neu overexpression has been used as a predictor of response to certain chemotherapeutic agents.