What is ZORBAX?
Zorbax 500mg Tablet is used to treat fungal infections of the skin, nails, scalp, or hair. This medicine is usually used when other medicines have failed to clear up the infection or are not appropriate. It kills the fungi and prevents them from growing on your skin.
What is difference between C18 and Phenyl column?
C18 has 18 carbon atoms while C8 has only 8 carbon atoms. C18 has a longer carbon chain, but C8 has a shorter one. C18 has higher retention while C8 has shorter retention. C18 has higher hydrophobicity, but C8 has a lower hydrophobicity….Follow Pharmaguideline.
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What is SB phenyl column?
Agilent ZORBAX SB-Phenyl is made by chemically bonding a sterically protected phenyl stationary phase to special ZORBAX silica, designed to reduce or eliminate strong adsorption of basic compounds. ZORBAX SB-Phenyl is especially suited for MS applications.
What is XDB column?
Dextromethorphan. eXtra Dense Bonding (XDB) is key to the exceptional performance of ZORBAX Eclipse XDB columns at intermediate pH (Figure 2). This dense bonding is accom- plished by adding an extra-dense mono- layer of C18, C8, phenyl, or CN-silane to the ultra-pure, fully-hydroxylated, ZORBAX Rx-silica surface.
Is C18 polar or nonpolar?
A C18 column is an example of a “reverse phase” column. Reverse phase columns are often used with more polar solvents such as water, methanol or acetonitrile. The stationary phase is a nonpolar hydrocarbon, whereas the mobile phase is a polar liquid.
Why C18 column is used in HPLC?
C18 columns are HPLC (high performance liquid chromatography) columns that use a C18 substance as the stationary phase. C18 simply means that the molecules contain 18 carbon atoms, so the other atoms in the molecule can vary, leading to significantly different substances.
What is zorbax eclipse?
ZORBAX columns are based on traditional fully porous particles and offer the highest loading capacity and resolution. From ZORBAX Eclipse Plus C18 to sub-2 micron UHPLC columms, a wide selection of stationary phases and particle sizes allows you to fine-tune your selectivity to match your application.
Why silica is used in HPLC column?
Generally, silica gel is filled in the high-performance liquid chromatography columns because of its particle size and porosity that helps in separation of components and silica gel is also an inert material that does not react with mobile phases. The material filled in the HPLC columns is known as a stationary phase.
What is packing in HPLC?
HPLC columns are usually packed with pellicular, or porous particles. Porous particles are made up silica, polystyrene-divinyl-benzene synthetic resin, alumina, or other type of ion-exchange resin. Silica is the most common type of porous particle packing material.
When to use zorbax sb-c18 at high temperature?
ZORBAX SB-C18 can be used at 90 °C at low pH and is therefore a good choice for higher temperature separations. High temperature can reduce mobile phase viscosity, lower operating pressure, and change band spacing (selectivity). Column Care. Samples should be filtered before injection into the column.
How does the Agilent zorbax extend-c18 column work?
The Agilent ZORBAX Extend-C18 column uses a novel bidentate C18-C18 bonding technology to make it possible to develop high-resolution separations at high pH with a silica-based column. At high pH, non-charged basic compounds will not interact with the underlying silica.
Which is the best zorbax column for low pH?
ZORBAX StableBond columns offer the highest stability for low pH applications down to pH 1 while ZORBAX SB-Aq deliver robust, reproducible separations with highly aqueous mobile phases, including 100% water ZORBAX Extend-C18 columns offer high efficiency for high pH applications up to pH 11.5
What kind of silica is a zorbax column made of?
ZORBAX Rx columns are made from highly pure (> 99.995 %) porous silica with a higher carbon load (12%) ZORBAX Eclipse PAH columns deliver high resolution separation of the 16 PAHs in EPA 610 and have been specifically tested with PAHs for maximum reproducibility View more on Agilent’s website