What is IFEX used for?
IFEX is indicated for use in combination with certain other approved antineoplastic agents for third-line chemotherapy of germ cell testicular cancer. It should be used in combination with mesna for prophylaxis of hemorrhagic cystitis.
How is ifosfamide toxicity treated?
The recommended dose of intravenous MB for treatment of ifosfamide-induced encephalopathy is 50 mg every 4 hours (1% aqueous solution over 5 minutes), whereas the dose for secondary prophylaxis of ifosfamide-induced encephalopathy is 50 mg every 6 hours, either intravenously or orally [8].
What kinds of chemicals are used in chemotherapy?
There are several types of alkylating agents used in chemotherapy treatments:
- Mustard gas derivatives: Mechlorethamine, Cyclophosphamide, Chlorambucil, Melphalan, and Ifosfamide.
- Ethylenimines: Thiotepa and Hexamethylmelamine.
- Alkylsulfonates: Busulfan.
Does IFEX cause hair loss?
Temporary hair loss frequently occurs in patients using this drug. Normal hair growth should return after treatment has ended. Many people using this medication have serious side effects.
What is another name for dacarbazine?
DTIC-Dome is the trade name for dacarbazine. DTIC and DIC or imidazole carboxamide are other names for dacarbazine. In some cases, health care professionals may use the trade name DTIC-Dome or other names DTIC or DIC or imidazole carboxamide when referring to the generic drug name dacarbazine.
When to tell your doctor about IFEX side effects?
Tell your doctor if you have any serious side effects of Ifex including: Ifex is administered intravenously at a dose of 1.2 g/m² per day for 5 consecutive days. Treatment is repeated every 3 weeks or after recovery from hematologic toxicity. Ifex may interact with “live” vaccines. Tell your doctor all medications and supplements you use.
What’s the trade name for the chemotherapy drug IFEX?
Ifex is the trade name for Ifosfamide. In some cases, health care professionals may use the trade name ifex when referring to the generic drug name ifosfamide. Drug type: Ifosfamide is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug.
What are the side effects of IFEX during pregnancy?
Ifex can cause fetal harm when administered to a pregnant woman. Fetal growth retardation and neonatal anemia have been reported following exposure to ifosfamide-containing chemotherapy regimens during pregnancy. Ifosfamide is genotoxic and mutagenic in male and female germ cells.
How much IFEX is in a single dose?
Ifex Description. Ifex (ifosfamide for injection, USP) single-dose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide.