What are the ingredients in clotrimazole?
Each gram of Clotrimazole Cream USP contains 10 mg clotrimazole USP, dispersed in a vanishing cream base of sorbitan monostearate, polysorbate 60, cetyl esters wax, cetostearyl alcohol, octyldodecanol, purified water, and benzyl alcohol (1%) as preservative.
How toxic is clotrimazole?
When clotrimazole is applied locally and topically, toxic effects such as pelvic cramps, hives, skin rash, occasional headache, itching, and irritation of the vulva and vagina may be observed. Stop the medication if there are any adverse effects.
What is clotrimazole derived?
Clotrimazole, 1-(o-chloro-α,α-diphenylbenzyl)imidazole (35.2. 21), is synthesized by reacting 2-chlorotriphenylmethylchloride (35.2. 20) with imidazole in the presence of triethylamine [33–37]. The starting substance 2-chlorotriphenylmethylchloride is made in various ways.
What is fluconazole derived from?
It is a difluorobenzene, a conazole antifungal drug, a triazole antifungal drug and a tertiary alcohol. It derives from a 1,3-difluorobenzene. It derives from a hydride of a 1H-1,2,4-triazole.
Is clotrimazole absorbed through the skin?
As previously mentioned, clotrimazole has very poor oral bioavailability. Less than 3% is absorbed from mucosal surfaces and less than 0.5% is absorbed through the skin. Most of the absorbed drug is metabolized on first pass through the liver.
Is clotrimazole bad for liver?
The cause of the serum enzyme elevations during clotrimazole therapy is unknown, but many of the antifungal azoles have been implicated in causing liver injury. Because there is minimal systemic absorption, clotrimazole concentrations may not reach levels that could cause significant liver injury.
Is clotrimazole natural?
Clotrimazole is a synthetic, imidazole derivate with broad-spectrum, antifungal activity.
Is clotrimazole a corticosteroid?
BETAMETHASONE; CLOTRIMAZOLE (bay ta METH a sone; kloe TRIM a zole) is a corticosteroid and antifungal cream. It treats ringworm and infections like jock itch and athlete’s foot. It also helps reduce swelling, redness, and itching caused by these infections.
What is the pH of clotrimazole?
The pH of clotrimazole cream formulations ranged from 4-7, which is a physiologically acceptable pH range and in principle devoid of any skin irritation. Clotrimazole content ranged from 90-110%, ensuring the uniformity of the drug content in all formulations.
Is fluconazole toxic?
Mechanism of Injury Fluconazole is a potent inhibitor of the cytochrome P450 enzyme CYP 3A4, and can lead to significant increases in plasma levels and serious toxicity from medications that are ordinarily metabolized by CYP3A4, particularly the statins and cyclosporine.
Why is fluconazole hazardous?
Repeat-dose studies in animals have shown a potential to cause adverse effects on liver. Known Clinical Effects: Adverse effects most commonly reported in clinical use include skin rash, headache, nausea, and abdominal pain. Rare cases of serious liver damage and allergic reactions have been reported.
What kind of medication is clotrimazole used for?
Clotrimazole is an antifungal medication. It is like an antibiotic but is used to treat yeast (fungal) infections. Oral clotrimazole is used to treat and prevent yeast infections of the mouth and throat. Clotrimazole may also be used for purposes other than those listed in this medication guide.
Is it safe to take clotrimazole over the counter?
Since clotrimazole is not absorbed by your body, drug interactions are not expected. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines.
How to use clotrimazole in home first aid kit?
For best results, cleanse the affected area with mild soap and warm water, pat dry and apply the medicated cream in a thin layer, twice daily. GLOBE brand Clotrimazole Medicated Cream is available in a convenient 1 oz tube and is an excellent addition to any home first aid kit.
How long does clotrimazole last for jock itch?
Clotrimazole does not work on the scalp or nails. If you are using clotrimazole to treat jock itch, your symptoms should improve over 2 weeks of treatment. If you are using clotrimazole to treat athlete’s foot or ringworm, your symptoms should improve over 4 weeks of treatment.