Does tigecycline cover Klebsiella?
Conclusions: Tigecycline demonstrated excellent inhibitory activity against the analyzed strains. These data suggest that tigecycline, with an expanded broad-spectrum antimicrobial activity, may be an effective therapeutic option for the treatment of serious infections caused by Klebsiella strains.
How do you treat carbapenem resistant Klebsiella?
The current components of an effective combination regimen recommended for treatment of CR-KP include high-dose carbapenem therapy administered by extended infusion (e.g., meropenem), which is combined with colistin and/or tigecycline, gentamicin or fosfomycin if susceptibility can be demonstrated.
What covers tigecycline?
Coverage includes many multidrug-resistant strains of gram-positive organisms, such as MRSA and MRSE, penicillin-resistant Streptococcus pneumoniae, and VRE species. Tigecycline has also shown activity against organisms that have developed resistance to tetracycline via various mechanisms.
Can we give meropenem and tigecycline together?
The triple combination of meropenem + tigecycline + colistin was bactericidal for isolates with MICs ≤256 mg/L. A low dose (50 mg) of tigecycline and a 0.5 h infusion of meropenem were less effective than a high dose (100 mg) of tigecycline and a 1 h infusion of meropenem.
How do you get infected with Klebsiella?
Klebsiella bacteria are mostly spread through person-to-person contact. Less commonly, they are spread by contamination in the environment. As with other healthcare-associated infections, the bacteria can be spread in a health care setting via the contaminated hands of health care workers.
Is Klebsiella a superbug?
A powerful superbug, a hypervirulent form of the bacteria Klebsiella pneumoniae, is a very difficult to curb infection. It causes a variety of infections including rare but life-threatening liver, respiratory tract, bloodstream and other infections.
Does CRE require isolation?
What isolation precautions are taken in the hospital if I have a CRE infection? Isolation precautions are steps we take to stop infections from spreading from person to person. If you’re diagnosed with or exposed to a CRE infection while you’re in the hospital: You will be placed in a private room.