What is the function of sarcoma?
Soft tissue sarcoma forms in the tissues that connect, support and surround other body structures. This includes muscle, fat, blood vessels, nerves, tendons and the lining of your joints.
What is intimal sarcoma?
Intimal sarcoma (IS) is defined as a malignant tumor arising in the tunica intima of large blood vessels. In systemic circulation, the majority of IS develop in the aorta, where close to three fourths of published cases lack specific differentiation and are called undifferentiated intimal sarcomas (UIS).
What happens when sarcoma spreads to the lungs?
The metastatic tumor is the same type of cancer as the primary tumor. For example, if soft tissue sarcoma spreads to the lung, the cancer cells in the lung are actually soft tissue sarcoma cells. The disease is metastatic soft tissue sarcoma, not lung cancer.
What cells are affected by sarcoma?
About soft-tissue sarcomas
| Name of Sarcoma | Related Normal Tissue Type |
|---|---|
| Fibrosarcoma | Fibroblasts, which are the most common type of cells in connective tissue |
| Gastrointestinal stromal tumor (GIST) | Specialized neuromuscular cells of the digestive tract |
| Kaposi sarcoma | Blood vessels |
| Leiomyosarcoma | Smooth muscle |
What is MDM2 fish?
MDM2 amplification by FISH is designed to detect amplification of the MDM2 gene to aid in patient diagnosis of soft tissue and bone tumors. In soft tissue tumors, MDM2 amplification is a frequent and specific finding in well differentiated liposarcoma/atypical lipomatous tumor (ref.
What is MDM2 gene?
Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor.
What kind of sarcomas have Mdm2 amplification?
The sarcomas in which MDM2 amplification is a hallmark are well-differentiated liposarcoma/atypical lipomatous tumor, dedifferentiated liposarcoma, intimal sarcoma, and low-grade osteosarcoma. The purpose of this review is to summarize the typical clinical, histopathological, immunohistochemical, and genetic features of these tumors.
What are the treatment options for intimal sarcomas?
Intimal sarcomas show MDM2 amplification with genetic aberration. Careful pre-operative planning to achieve clear surgical margins almost doubles life expectancy. Chemoradiotherapy may be beneficial. MDM2 and PDGFRa inhibitors are in development.>
What is the function of Mdm2 in cancer?
The most important function of MDM2 is to control p53 activity; it is in fact the best documented negative regulator of p53. Mutations of the tumor suppressor gene p53 represent the most frequent genetic change in human cancers. By overexpressing MDM2, cancer cells have another means to block p53.
What kind of tumor is an intimal sarcoma?
Image shows tumor cells with clustering of MDM2 gene in a ratio of MDM2:centromere of >2.0 typical of intimal sarcomas. Intimal sarcomas are highly aggressive mesenchymal tumors classified as undifferentiated sarcomas [1], [2], [5], [7]. They typically involve large vessels arising from intimal subendothelial cells [1], [4], [5].