What causes ectopic ossification?
Causes. Heterotopic ossification of varying severity can be caused by surgery or trauma to the hips and legs. About every third patient who has total hip arthroplasty (joint replacement) or a severe fracture of the long bones of the lower leg will develop heterotopic ossification, but is uncommonly symptomatic.
When does ectopic ossification occur?
HO usually occurs 3-12 weeks after spinal cord injury yet has been known to also develop years later.
What is ectopic bone formation?
Ectopic refers to an object or human tissue that forms or is located where it does not belong. Ectopic bone formation is the laying down of new bone material (via a process called ossification) in areas, again, where this material does not belong.
How is ossification treated?
The two main treatments available are radiation therapy and NSAIDs. Bisphosphonates have been used in the past, but their use has been discontinued as they only postpone ossification until treatment is stopped.
How do I get rid of ossification?
Currently, “there’s no way to prevent it and once it’s formed, there’s no way to reverse it,” says Benjamin Levi, M.D., Director of the Burn/Wound/Regeneration Medicine Laboratory and Center for Basic and Translational Research in Michigan Medicine’s Department of Surgery.
What is the difference between calcification and ossification?
Ossification (or osteogenesis) in bone remodeling is the process of laying down new bone material by cells named osteoblasts. Calcification is synonymous with the formation of calcium-based salts and crystals within cells and tissue. It is a process that occurs during ossification, but not necessarily vice versa.
Why does ossification happen?
bone formation, also called ossification, process by which new bone is produced. Soon after the osteoid is laid down, inorganic salts are deposited in it to form the hardened material recognized as mineralized bone. The cartilage cells die out and are replaced by osteoblasts clustered in ossification centres.
How can you prevent ossification?
NSAIDs and radiation therapy are currently considered the gold standard in HO prevention [16, 17]. They act by modifying the microenvironment as they reduce the associated inflammatory process involved in HO formation.
Does ossification cause pain?
Heterotopic ossification is abnormal bone formation within muscle and soft tissues, an unfortunately common phenomenon that typically occurs weeks after an injury or surgery. Patients with heterotopic ossification experience decreased range of motion, swelling and pain.
What does heterotopic bone formation mean?
Heterotopic ossification (HO), also known as heterotopic bone formation, is the presence of bone in soft tissue where bone normally does not exist. This condition should not be confused with metastatic calcification—such as may be seen with hypercalcemia—and dystrophic calcification,…
What is the medical definition of ossification?
Medical Definition of ossification. 1a : the process of bone formation usually beginning at particular centers in each prospective bone and involving the activities of special osteoblasts that segregate and deposit inorganic bone substance about themselves — compare calcification sense a. b : an instance of this process.
What is soft tissue ossification?
Ossification It is a natural process of the body in which soft tissues turn into a bony substance. However, in some cases, bone development occurs beyond the confines of the skeleton, which is commonly referred to as heterotopic ossification.