What is the Cox 2 gene?
Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes, EC 1.14….Cyclooxygenase.
| cyclooxygenase 2 | |
|---|---|
| NCBI gene | 5743 |
| HGNC | 9605 |
| OMIM | 600262 |
| PDB | 6COX |
What is the function of COX 2?
Cox-2 is the inducible form of cyclo-oxygenase and catalyzes the conversion of arachidonic acid to prostaglandins. Cox-2 is expressed by inflammatory cells, such as macrophages, and can be induced by TNF and EGF.
Is Cox 2 an aging gene?
As mentioned earlier, COX2 is involved in the development and/or progression of many age-related diseases including atherosclerosis, arthritis, cancer, diabetes, osteoporosis, and Alzheimer’s disease [8–14]. Moreover, studies have reported that COX2 expression is increased during aging.
What is PTGS2 gene?
PTGS2 (Prostaglandin-Endoperoxide Synthase 2) is a Protein Coding gene. Diseases associated with PTGS2 include Gastric Ulcer and Bursitis. Among its related pathways are p70S6K Signaling and ERK Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and lipid binding.
What do COX-2 inhibitors do?
COX-2 inhibitors are a newer type of NSAID that block the COX-2 enzyme at the site of inflammation. The benefit of COX-2 inhibitors is that they do not inhibit COX-1, an enzyme that helps with the production of the protective stomach lining.
Is COX-2 a mutant gene?
Mutation of the COX2 gene can double or treble a woman’s risk of ovarian cancer. Barcelona, Spain: Researchers in Portugal have discovered that a specific mutation of the COX2 gene seems to play a role in the onset of ovarian cancer, increasing women’s susceptibility to developing the disease.
What are Endoperoxides?
Endoperoxides are a known class of antimalarial agents, which include the natural product artemisinin (a tetracyclic trioxane) and its semisynthetic derivatives antemether, arteether, artesunic acid, and artelinic acid.
Is aspirin 1 or 2 Cox?
Aspirin inhibits COX-1 (cyclooxygenase-1). Its effect on COX-2 is more delicate: it “turns off” COX-2’s production of prostaglandins but “switches on” the enzyme’s ability to produce novel protective lipid mediators. Aspirin is a widely used non-steroidal anti-inflammatory drug (NSAID).
Which of the following is a COX-2 inhibitor?
Celecoxib is the only COX-2 inhibitor currently available in the United States. Rofecoxib (Vioxx) and valdecoxib (Bextra) are no longer available because they increased the risk of heart attacks and strokes with long term use.