How long until Sutent side effects start?
Dosage for the adjuvant treatment of kidney cancer The usual dosage of Sutent for this use is 50 mg once per day for 4 weeks. This is followed by 2 weeks without medication.
Does sunitinib cause hyponatremia?
However, the role of hyponatremia in mRCC patients treated with targeted therapies is not well defined. One study including 87 mRCC patients treated with sunitinib or sorafenib showed that hyponatremia was significantly associated with cancer-specific survival [14].
How long can you take sunitinib?
Recommended dosage for advanced renal cell carcinoma (RCC) SUTENT is taken once every day for 4 weeks (28 days), then it is stopped for 2 weeks (14 days). This is 1 cycle of treatment. This cycle is repeated for as long as your doctor tells you to.
Can you drink alcohol while taking imatinib?
Avoid grapefruit and grapefruit juice for the duration of your treatment, as these may interact with imatinib. The drinking of alcohol (in small amounts) does not appear to affect the safety or usefulness of imatinib.
How long does imatinib stay in your system?
Imatinib has a half-life of around 18 hours. A drug’s half-life is the time it takes for your body to clear half of a dose of the drug.
How long does sunitinib take to work?
Sutent is a cancer medication that is taken as an oral capsule. Sutent reaches peak blood levels within 6 to 12 hours, which is when it starts to have its effect of reducing cancer growth and spread.
Can multiple myeloma cause hyponatremia?
The hyponatremia found in multiple myeloma and which is associated with a reduced anion gap (ag) is considered to be pseudohyponatremia due to the displacement of water by the high globulin content in the blood.
What are the side effects of sunitinib malate?
Other side effects include: severe hypertension. See below for a comprehensive list of adverse effects. Hepatotoxicity may be severe, and in some cases, fatal. Monitor hepatic function and interrupt, dose reduce, or discontinue sunitinib malate as recommended.
When to discontinue sunitinib therapy for renal cell carcinoma?
Typically, if more than 2 dose reductions are required (total dose reduction > 25 mg), it is preferable to discontinue sunitinib therapy or rechallenge the patient after recovery from side effects. Recovery to acceptable levels of toxicity should occur within 4 weeks before sunitinib therapy can be continued.
When to reduce the dose of sunitinib for diarrhea?
The sunitinib dose should be reduced by 1 dose level (12.5mg) in subsequent cycles in cases of grade 3 or 4 diarrhea, based on the dose modifications made in the Sutent studies and the recommendations given in the product monograph. 1, 2, 3, 6
What happens when Sunitinib is combined with domperidone?
However, particular care should be used when sunitinib is combined with antidopaminergic agents such as domperidone, or 5HT3 antagonists, such as granisetron, ondansetron, and dolasetron, because they have been associated with QT/QTc interval prolongation or torsade de pointes (see Cardiac toxicity).