Is it OK to take hydrochlorothiazide while pregnant?

Is it OK to take hydrochlorothiazide while pregnant?

Experts recommend avoiding hydrochlorothiazide, or HCTZ (Aquazide H, Diaqua, Hydrocot and others) during pregnancy unless its benefits clearly outweigh its potential risks. HCTZ has not been studied well in pregnant women, but it is known to pass through the placenta to a developing fetus.

Why are thiazide diuretics contraindicated in pregnancy?

Thiazide diuretics may, however pose metabolic risks to the mother and fetus (hyponatremia, hypokalemia, thrombocytopenia, hyperglycemia), and may have a direct effect on smooth muscle, resulting in inhibition of labor.

Why are diuretics avoided during pregnancy?

Diuretics do not cause fetal malformations but are generally avoided in pregnancy, as they prevent the physiologic volume expansion seen in normal pregnancy. They may be used in states of volume-dependent hypertension, such as renal or cardiac disease.

What diuretics are safe during pregnancy?

Loop diuretics, especially furosemide (C), have been used in pregnancy to treat pulmonary edema, severe hypertension in the presence of chronic kidney disease, or congestive heart failure despite the potential risk of neonatal hyperbilirubinemia (Turmen et al. 1982).

What is the pregnancy category for hydrochlorothiazide?

US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Which is an appropriate choice for hypertension treatment during pregnancy?

According to NHBPEP methyldopa, labetalol, beta blockers (other than atenolol), slow release nifedipine, and a diuretic in pre-existing hypertension are considered as appropriate treatment [1].

What pregnancy category is hydrochlorothiazide?

What are the side effects from hydrochlorothiazide?

The more common side effects that can occur with hydrochlorothiazide include:

• blood pressure that’s lower than normal (especially when standing up after sitting or lying down)
• dizziness.
• headache.
• weakness.
• erectile dysfunction (trouble getting or keeping an erection)
• tingling in your hands, legs, and feet.

What is the safest blood pressure medication during pregnancy?

Methyldopa has been used for decades to treat high blood pressure in pregnancy and it appears to be safe. Labetalol has been extensively studied and has become increasing prescribed in pregnancy. Labetalol is now commonly used as a first-line treatment choice.

Which hypertensive drug is safe in pregnancy?

The choice of antihypertensive drugs also is discussed; methyldopa, labetalol, and nifedipine, among others, appear safe for use in pregnancy, whereas angiotensin converting enzyme inhibitors and angiotensin receptor blockers should be avoided.

Can I take blood pressure meds while pregnant?

Some blood pressure medications are considered safe to use during pregnancy, but angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers and renin inhibitors are generally avoided during pregnancy.

How many women were exposed to hydrochlorothiazide during pregnancy?

This was a retrospective study of 229,101 completed pregnancies between 1985 and 1992, of which 567 were exposed to hydrochlorothiazide at some time during the first trimester, and 1,173 were exposed to the drug at any time during pregnancy.

What do you need to know about the reprotox system?

The REPROTOX® system was developed as an adjunct information source for clinicians, scientists, and government agencies. Patients should consult their health care providers rather than relying on REPROTOX® summaries. Forgot your login? If you want to renew but don’t remember your login, we can find you.

Is it safe to take hydrochlorothiazide while breastfeeding?

Hydrochlorothiazide Breastfeeding Warnings. Manufacturer recommendation: Use is not recommended and a decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. Excreted into human milk: Yes.

Is it safe to take thiazide diuretics during pregnancy?

There are no data from controlled human studies, but retrospective reviews have shown an increased risk of malformations associated with thiazide diuretics. In addition, use of thiazide diuretics during pregnancy has been associated with fetal or neonatal electrolyte abnormalities, jaundice, and/or thrombocytopenia.