What is Alejandro Zaffaroni famous for?
Alejandro Zaffaroni (February 27, 1923 – March 1, 2014) was a serial entrepreneur who was responsible for founding several biotechnology companies in Silicon Valley. Products that he was involved in developing include the birth control pill, the nicotine patch, corticosteroids, and the DNA microarray.
How did Alejandro Zaffaroni die?
Dementia
Alejandro Zaffaroni/Cause of death
What did Alejandro Zaffaroni invent?
Alejandro Zaffaroni was a biotechnology innovator whose early work with controlled drug delivery methods, particularly his early concepts for transdermal patches, led to the growth of research into innovative drug delivery systems.
Where is Alejandro Zaffaroni from?
Montevideo, Uruguay
Alejandro Zaffaroni/Place of birth
Zaffaroni, who died on 1 March aged 91, was born in Montevideo, Uruguay. He studied for his bachelor’s degree there, and in the last days of the Second World War he boarded a military cargo ship to New York, where he gained a PhD in biochemistry at the University of Rochester.
What does a transdermal patch do?
Transdermal patches deliver drugs topically, where they are absorbed by the skin and into the bloodstream. They provide a consistent delivery of small amounts of a drug into the blood stream over a long period of time. The length of wear time and the amount of drug delivered is different from patch to patch.
Why was transdermal invented?
This 1970s work culminated in the Alza Corporation developing a transdermal therapeutic system (TTS) for prevention and treatment of motion-induced nausea designed to provide controlled administration of scopolamine through the surface of the skin, such that the system governed drug input kinetics to the systemic …
What are the disadvantages of transdermal patches?
Disadvantages of transdermal route of drug administration The drug, the adhesive, or excipients in the patch formulation may cause rashes, local irritation, erythema, or contact dermatitis.
How long does it take for a transdermal patch to work?
Your patch will take approximately 12 to 24 hours to reach peak pain controlling levels. During this time you may have be instructed to continue to use other opioid medication. How long will I have to wear Fentanyl patches for?
Is instillation administration via the mouth?
Instillation. Instillation is in the form of liquid and enters the body via the eyes, nose or ears. Ear drops can be used to clear up build up of wax, eye drops are used for eye infections and for people that have allergies such as hay fever can use sprays that are administrated via the nose.
How are patches handled?
Remove the patch from its pouch and peel off half of its protective liner. Place the adhesive side on the skin, then peel off the other half of the liner. Press the skin patch firmly with the palm of your hand for at least 30 seconds, making sure it adheres to the skin, especially at the edges. Figure.
How effective is transdermal patch?
When used correctly, the patch is more than 99% effective at preventing pregnancy. Each patch lasts for 1 week.