Is witepsol water soluble?
Suitable for both rectal and vaginal use. Solubility: Witepsol®H15 is readily soluble in diethylether, toluene and n-hexane and slightly soluble in anhydrous ethanol and methylene chloride. Practically insoluble in water.
What is witepsol made of?
Description: It consists of glycerol esters of vegetable saturated fatty acids, mainly lauric acid and is derived from coconut and palm kernel oils.
What is witepsol used for?
They are mainly used for the production of suppositories and ovules. Nice to know: The brand name WITEPSOL® is a combination of the production location Witten and the Latin name for „hard fat“ = Adeps solidus….PRODUCTS.
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What is meant by witepsol?
WITEPSOL® products of series E are hard fat compounds having a melting point above body temperature. They are used if active compounds lower the melting point of the excipient because of their fat solubility. They are characterized by their melting point and hydroxyl value.
What is the purpose of a suppository?
Suppositories are another way to deliver drugs to the body when other routes, such as oral, cannot be used. A suppository is small and may be round, oval, or cone-shaped. A substance, such as cocoa butter or gelatin, surrounds the medication. The suppository dissolves to release the drug once inside the body.
What are the advantages of a suppository?
The primary advantages of suppositories over other dosage forms include reduced first pass metabolism, both topical and systemic effect, accommodates patients who have difficulty swallowing pills, and increased bioavailability of drugs.
Can you use beeswax in suppositories?
In conclusion, by using solid fats such as HB750 and beeswax with relatively high melting points, it is possible to control the rate of drug release from fatty base suppositories for maintaining the plasma concentration of drugs for longer time periods.
Why is gelatin used in suppositories?
Glycerinated Gelatin is particularly used for vaginal suppositories. Glycerinated gelatin suppositories tend to disperse slowly in mucous secretions thus to provide prolonged release of active ingredients.
Why cocoa butter is not used in the preparation of pessaries?
First, this base must not be heated above 35°C (95°F) because cocoa butter is a polymorphic compound and if overheated will convert to a metastable structure that melts in the 25° to 30°C (77° to 86°F) range. Thus, the finished suppositories would melt at room temperature and not be usable.
What is hard fat in pharmaceutical?
The rendered fat of swine, lard, used in the preparation of ointments. See also: adeps lanae.
What is hard fat ingredient?
Active Ingredients (in each suppository) Hard Fat 88.44% Phenylephrine hydrochloride 0.25% Hard Fat 88.44% Phenylephrine hydrochloride 0.25%
Does suppository dissolve?
A suppository is another way to deliver a drug. It’s a small, round or cone-shaped object that you put in your body, often into your bottom. Once it’s inside, it melts or dissolves and releases its medication.
What is the melting point of Witepsol 45?
WITEPSOL®W 45 is a special grade which is characterized by a higher monoglyceride content of up to 15%, which supports increased absorption promotion of active compounds and faster solidification. WITEPSOL®W 32 melting point 32–33.5 °C HV = 40–50
What kind of oil is used for Witepsol?
A high solubility of the drug will minimize the volume of the formulation necessary to deliver the therapeutic agent ( Talegaonkar and Negi, 2015). Oils used in nanoemulsion formulations are Captex 355, Captex 8000, Witepsol, Myritol 318, Capryol 90, Sefsol-218, triacetin, isopropyl myristate, castor oil, and olive oil (Chime et al., 2014 ).
What is the hydroxyl value of witepsolh15?
Witepsol®H15 has a hydroxyl value of 5-15. It is used as a compound for suspension suppositories having a proportion of solid active compounds of less than 25%. **During summer months, it is recommended to ship suppository bases expedited due to the melting temperature of the product.
What kind of suppository base is Witepsol H15?
Witepsol®H15 is an NF grade, small pastille form suppository base comprised of glycerides from vegetable origins with a long history of use with a wide range of APIs. Suitable for both rectal and vaginal use.