What is receptor theory in pharmacology?
Receptor theory is the application of receptor models to explain drug behavior. Pharmacological receptor models preceded accurate knowledge of receptors by many years. John Newport Langley and Paul Ehrlich introduced the concept of a receptor that would mediate drug action at the beginning of the 20th century.
What is the receptor theory of drug action?
The main points to describe receptor theory are: Drugs interact with receptors in a reversible manner to produce a change in the state of the receptor. This interaction can be modeled mathematically and follows the Law of Mass Action.
What are the 4 types of receptors in pharmacology?
Receptors can be subdivided into four main classes: ligand-gated ion channels, tyrosine kinase-coupled, intracellular steroid and G-protein-coupled (GPCR). Basic characteristics of these receptors along with some drugs that interact with each type are shown in Table 2.
What are the theories of drug actions?
A theory of drug action is developed on the assumption that excitation by a stimulant drug is proportional to the rate of drug-receptor combination, rather than to the proportion of receptors occupied by the drug.
What are types of receptors?
There are two types of receptors: internal receptors and cell-surface receptors.
What is the first receptor?
Discovery of the First Neurotransmitter Receptor: The Acetylcholine Nicotinic Receptor.
What is the function of the receptor?
Receptors are a special class of proteins that function by binding a specific ligand molecule. When a ligand binds to its receptor, the receptor can change conformation, transmitting a signal into the cell.
What is the role of receptor?
Receptors are a special class of proteins that function by binding a specific ligand molecule. When a ligand binds to its receptor, the receptor can change conformation, transmitting a signal into the cell. In some cases the receptors will remain on the surface of the cell and the ligand will eventually diffuse away.
What is drug receptor?
7.2 Drug receptors. Receptor is a macromolecule in the membrane or inside the cell that specifically (chemically) bind a ligand (drug). The binding of a drug to receptor depends on types of chemical bounds that can be established between drug and receptor.
What is receptor occupancy?
A receptor occupancy assay measures the degree to which the test drug occupies its target receptor in the tissue or animal. Receptor occupancy is determined by measuring the ability of a dose of the test drug to compete with binding of a radiotracer to the receptor.
What are receptor examples?
Hundreds of different G-protein-linked receptors have been identified. Well-known examples include the β-adrenergic receptor, the muscarininc type of acetylcholine receptor, metabotropic glutamate receptors, receptors for odorants in the olfactory system, and many types of receptors for peptide hormones.
What is the role of a drug receptor?
A drug receptor is a specialized target macromolecule that binds a drug and mediates its pharmacological action. These receptors may be enzymes, nucleic acids, or specialized membrane-bound proteins. The formation of the drug-receptor complex leads to a biological response.
How does the formation of a receptor complex lead to a biological response?
The formation of the drug-receptor complex leads to a biological response. The magnitude of the response is proportional to the number of drug-receptor complexes. A common way to present the relationship between the drug concentration and the biological response is with a concentration- (or dose-) response curve ( Figure 2–1 ).
Which is the best classification of the receptors?
Classification of Receptors 1. G Protein coupled receptors epinephrine, serotonine, glucagon 2. Ion channel receptors acetylcholine receptor . 3. Tyrosine kinase-linked receptors cytokine-receptor family . 4. Receptors with intrinsic enzymatic activity the receptor has intrinsic catalytic activity . receptor tyrosine kinases
Which is a family of G protein coupled receptors?
1. G Protein coupled receptors epinephrine, serotonine, glucagon 2. Ion channel receptors acetylcholine receptor 3. Tyrosine kinase-linked receptors cytokine-receptor family 4. Receptors with intrinsic enzymatic activity the receptor has intrinsic catalytic activity receptor tyrosine kinases