What enzyme does aliskiren inhibit?

What enzyme does aliskiren inhibit?

Aliskiren is a non-peptide drug that competitively inhibits the enzyme, renin. Aliskiren is referred to as a direct renin inhibitor. Renin catalyzes the conversion of angiotensinogen to angiotensin I which is the first and rate-limiting step in the renin–angiotensin– aldosterone system.

Is aliskiren and ACE inhibitor?

Aliskiren is an orally-active, nonpeptidic, direct inhibitor of renin which simultaneously reduces angiotensin I, angiotensin II and plasma renin activity (PRA). This is the main point of action of aliskiren, making it completely different from ACE inhibitors and ARBs.

Can aliskiren and losartan be taken together?

Interactions between your drugs Using aliskiren together with losartan may increase the risk of serious side effects such as kidney problems, low blood pressure, and high potassium levels in the blood.

Is aliskiren in losartan?

Aliskiren (300 mg) added to losartan (100 mg) plus optimal antihypertensive therapy provides antiproteinuric effects independent of BP in patients with type 2 diabetes and nephropathy. Renal function was better preserved with aliskiren in patients with insufficient BP control.

What is aliskiren drug used for?

Aliskiren is used alone or in combination with some medications to treat high blood pressure. Aliskiren is in a class of medications called direct renin inhibitors. It works by decreasing certain natural chemicals that tighten the blood vessels, so blood vessels relax and the heart can pump blood more efficiently.

Why is aliskiren contraindicated with ACE inhibitors?

Concomitant use of aliskiren with ARBs or ACEIs in patients with diabetes is contraindicated because of the risk of renal impairment, hypotension, and hyperkalemia. Valturna (a combination drug containing aliskiren and valsartan) should not be used in patients with diabetes.

What class of drug is aliskiren?

Aliskiren is in a class of medications called direct renin inhibitors. It works by decreasing certain natural chemicals that tighten the blood vessels, so blood vessels relax and the heart can pump blood more efficiently.

Is aliskiren a diuretic?

Aliskiren works by relaxing blood vessels so blood can flow more easily. It belongs to a class of drugs known as direct renin inhibitors. Hydrochlorothiazide causes your body to get rid of extra salt and water by making more urine. It is called a “water pill” or diuretic.

Can you mix losartan and lisinopril?

Should I take lisinopril and losartan together? No. Although some blood pressure medications are used in combination (such as losartan or lisinopril in combination with a diuretic), lisinopril and losartan should not be taken together.

Who makes aliskiren?

A warning to avoid use of aliskiren with ARBs or ACEIs was also added for patients with moderate to severe kidney impairment (i.e., where glomerular filtration rate is less than 60 ml/min). Novartis decided to stop marketing Valturna (aliskiren/valsartan).

What type of drug is aliskiren?

Aliskiren is a renin inhibitor used to treat high blood pressure (hypertension) by lowering blood pressure. Aliskiren is found in the following medications: Amturnide (aliskiren hemifumarate, amlodipine besylate, and hydrochlorothiazide) Tekturna (aliskiren hemifumarate)

What drugs have aliskiren?

Aliskiren is found in the following medications:

• Amturnide (aliskiren hemifumarate, amlodipine besylate, and hydrochlorothiazide)
• Tekturna (aliskiren hemifumarate)
• Tekturna HCT (aliskiren hemifumarate and hydrochlorothiazide)
• Tekamlo (aliskiren hemifumarate and amlodipine besylate)

Is it safe to take aliskiren with ACEis?

[4-20-2012] The U.S. Food and Drug Administration (FDA) is warning of possible risks when using blood pressure medicines containing aliskiren with other drugs called angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in patients with diabetes or kidney (renal) impairment.

Where can I find a list of aliskiren medicines?

The labels for the aliskiren drugs are being updated based on preliminary data from a clinical trial, “ Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE) .” A list of medicines containing aliskiren is found in the Drug Facts box. Lists of approved ACEIs and ARBs are found in Tables 2 and 3.

What are the risks of taking aliskiren with an ARB?

Lists of approved ACEIs and ARBs are found in Tables 2 and 3. In ALTITUDE, the risks of kidney (renal) impairment, low blood pressure (hypotension), and high potassium blood levels (hyperkalemia) in a group of patients taking aliskiren plus an ARB or ACEI increased relative to a group of patients taking placebo plus an ARB or ACEI.

What kind of blood pressure medication is aliskiren?

Aliskiren is a renin inhibitor used to treat high blood pressure (hypertension) by lowering blood pressure. Aliskiren is found in the following medications: Amturnide (aliskiren hemifumarate, amlodipine besylate, and hydrochlorothiazide)