What is the reversal agent for Lexiscan?
period was 5.6. In pharmacologic stress tests, Lexiscan was the choice for 92.59% of the hospitals. Ninety two percent of hospitals reported that aminophylline was the reversal agent of choice while caffeine-containing beverages are used 85.19% of the time.
Is there a substitute for aminophylline?
Adenosine and dobutamine can be used as alternatives to regadenoson and dipyridamole to decrease or eliminate the use of aminophylline. Alternatives to aminophylline include theophylline and caffeine.
What is the reversal for adenosine?
5 Aminophylline is a nonselective adenosine receptor antagonist that has been used to reverse the adverse effects of regadenoson, adenosine, and dipyridamole.
Which of the following is an absolute contraindication to administering Lexiscan regadenoson )?
Absolute Contraindications: Asthmatic patients with active ongoing wheezing should not undergo Lexiscan stress testing. However, patients with adequately controlled asthma can undergo adenosine stress test and can have pre-treatment with 1-2 puffs of Albuterol or comparable inhaler.
When does Lexiscan go generic?
Lexiscan was eligible for patent challenges on April 10, 2012. By analyzing the patents and regulatory protections it appears that the earliest date for generic entry will be February 2, 2027. This may change due to patent challenges or generic licensing.
How long after Lexiscan Can you give aminophylline?
7.1 Effects of Other Drugs on LEXISCAN Patients should avoid consumption of any products containing methylxanthines as well as any drugs containing theophylline or aminophylline for at least 12 hours before LEXISCAN administration.
Is aminophylline used in asthma?
Aminophylline is used to prevent and treat wheezing, shortness of breath, and difficulty breathing caused by asthma, chronic bronchitis, emphysema, and other lung diseases. It relaxes and opens air passages in the lungs, making it easier to breathe.
What is the generic name for aminophylline?
Theophylline is available under the following different brand names: Theo 24, Theochron, Elixophyllin, aminophylline, and Uniphyl.
What is a lexiscan for the heart?
Lexiscan or Adenoscan are administered by intravenous injection during a cardiac nuclear stress test to patients who cannot adequately exercise. These drugs dilate the coronary arteries and increase blood flow so that coronary artery obstructions can be identified.
What is the antidote for dobutamine?
Side effects of dobutamine can be reverted by metoprolol (1–5 mg) or esmolol intravenously, if chest pain or arrhythmias do not resolve after termination of dobutamine infusion.
Does aminophylline increase blood pressure?
Aminophylline increased mean arterial pressure 12 +/- 2%, LV systolic pressure 8 +/- 1%, LV dP/dt 20 +/- 2%, velocity of myocardial fiber shortening 13 +/- 2% and heart rate 5 +/- 2%, and reduced LV end-diastolic diameter 2 +/- 0.5%.
Will there be a generic for Xarelto in 2021?
As of March 2019, there is no generic available for Xarelto. However, it may become available as generic rivaroxaban in 2021, when the patent for the brand drug expires. While you might have to wait two more years to save with the generic, there are other ways to cut costs on Xarelto in the meantime.
What to do when there is a shortage of aminophylline?
With periodic shortage of aminophylline, selective use of reversal agents is a reasonable alternative to routine use and does not compromise safety or effectiveness of testing.
How much aminophylline should I take for Lexiscan?
Aminophylline is an adenosine antagonist, which may be used to shorten the duration of increased coronary blood flow induced by Lexiscan. Aminophylline has been used to terminate persistent pharmacodynamic effects. Aminophylline may be administered in doses ranging from 50 mg to 250 mg by slow IV injection (50 mg to 100 mg over 30-60 seconds).
Is there a shortage of aminophylline for vasodilator stress?
Pharmacologic reversal of serious or intolerable side effects (SISE) from vasodilator stress is an important safety and comfort measure for patients experiencing such effects. While typically performed using intravenous aminophylline, recurrent shortages of this agent have led to a greater need to limit its use and consider alternative agents.
Is the aminophylline injection the best practice as a reversal?
With the increased use of vasodilatation drugs, there is an increased amount of side effects. The use of aminophylline as a reversal agent for these side effects in pharmacologic nuclear stress testing has become common practice.