What is BCLC staging?

What is BCLC staging?

The BCLC system stratifies HCC patients based on tumor size, extent, liver function, and performance status. The BCLC staging system is thought to be better than other staging systems for determining prognosis, given the inclusion of liver function and performance status.

What is BCLC B?

The BCLC staging system You feel well and are active (PS 0), and your liver is working well (Child-Pugh A or B). Stage B (Intermediate Stage) This means there are many tumours in the liver, but you feel well (PS 0) and your liver is working well (Child-Pugh A or B). Stage C (Advanced stage)

What is the best treatment for HCC?

Orthotopic liver transplantation (OLT) is an effective treatment for both HCC and underlying cirrhosis, and is considered the best therapeutic option. Unfortunately, most cases of HCC present in an advanced stage and are not suitable candidates for OLT[2].

What is the pathophysiology of liver cancer?

Hepatocellular carcinoma (HCC) primarily arises in a cirrhotic liver, where repeated inflammation and fibrinogenesis predispose the liver to dysplasia and malignant transformation.

How is Albi score calculated?

Johnson and colleagues introduced a new model for liver function assessment only based on albumin and bilirubin and termed the albumin-bilirubin (ALBI) grade. The formula for this scoring system relies on the following equation: ALBI score = (log10 bilirubin [µmol/L] × 0.66) + (albumin [g/L] × −0.0852).

How the staging of HCC is done?

Okuda staging system was proposed in 1985 based on a study of 850 HCC patients. This system is the first to combine tumor size (≤ or > 50% of the entire liver) with the variables of liver function such as ascites (presence and absence), serum albumin (≤ or > 3.0 g/dL) and bilirubin levels (≤ or > 3.0 mg/dL).

How successful is TACE procedure?

TACE is a treatment, not a cure. Approximately 70 percent of the patients will see improvement in the liver and, depending on the type of liver cancer, it may improve survival rates and quality of life.

Is HCC curable?

Most people who develop HCC have cirrhosis, which is a build-up of scar tissue due to years of liver damage. Since HCC usually grows slowly in its early stages, it can often be cured if discovered early enough.

What is PLCC in medicine?

Primary liver cell carcinoma (PLCC), predominantly hepatocellular carcinoma is a killer.

How does hepatocellular carcinoma develop?

This serious disease happens when liver cells are damaged and replaced with scar tissue. Many things can cause it: hepatitis B or C infection, alcohol drinking, certain drugs, and too much iron stored in the liver.

What is Albi grade?

Are there any MRIs of liver with hepatocellular carcinoma?

Although imaging characteristics may be suggestive, a significant overlap may occur between the tumor and regenerative nodules. MRI of a liver with hepatocellular carcinoma. The benefits of contrast-enhanced studies must be balanced against the risks if any anatomic or functional renal impairment is possible.

How is hepatocellular carcinoma ( HCC ) diagnosed?

Author: Luca Cicalese, MD, FACS; Chief Editor: John Geibel, MD, MSc, DSc, AGAF more… The diagnosis of hepatocellular carcinoma (HCC) can often be established on the basis of noninvasive imaging, without biopsy confirmation.

What is the Barcelona clinic liver cancer staging system?

The barcelona clinic liver cancer staging system (BCLC) is the most commonly used HCC management guideline. For BCLC stage B (intermediate HCC), transarterial chemoembolization (TACE) is the standard treatment. Many studies support the use of TACE in early and advanced HCC patients.

Can You biopsy a hepatocellular carcinoma lesion?

The decision to biopsy a lesion suspected of being hepatocellular carcinoma is the subject of ongoing controversy.