Which cells express CXCL9?
CXCL9, -10, -11 are mainly secreted by monocytes, endothelial cells, fibroblasts, and cancer cells in response to IFN-γ, which are synergistically enhanced by TNF-alpha.
What is the receptor for CXCL9?
CXCL9, CXCL10 and CXCL11 each bind to a common primary receptor, CXCR3, and possibly to additional receptors. They are best known for their role in leucocyte trafficking, principally acting on activated CD4+ Th1 cells, CD8+ T cells and NK cells.
Is CXCL9 a cytokine?
Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as monokine induced by gamma interferon (MIG).
How do I lower my CXCL9 levels?
Moreover, CXCL9 expression can be suppressed by reducing the levels of components of the STAT1‐IRF‐1(IRF‐1, Interferon regulatory factor) transcriptional activation pathway by Porphyromonas gingivalis that leads to the immune function decline 14.
What produces CXCL10?
CXCL10 (interferon-γ-inducible protein 10, previously called IP-10) was initially discovered as a chemokine which is induced by interferon (IFN)-γ and is produced by a wide range of cell types including monocytes [15], neutrophils [16], endothelial cells [17], keratinocytes [18], fibroblasts [19], mesenchymal cells [20 …
What is MIP3A?
Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils.
What does an interferon do?
Interferons are proteins that are part of your natural defenses. They tell your immune system that germs or cancer cells are in your body. And they trigger killer immune cells to fight those invaders. Interferons got their name because they “interfere” with viruses and keep them from multiplying.
Which immune cells produce interferon gamma?
Interferon-gamma is secreted predominantly by activated lymphocytes such as CD4 T helper type 1 (Th1) cells and CD8 cytotoxic T cells (23–26), γδ T cells (27–33), and natural killer (NK) cells (34, 35) and, to a less extent, by natural killer T cells (NKT), B cells (36–39), and professional antigen-presenting cells ( …
Is CXCL10 pro inflammatory?
CXCL10 in Respiratory Diseases. CXCL10 has been associated with a wide spectrum of lung inflammatory diseases through both pro- and antifibrotic effects and its ability to recruit cells that secrete or respond to IFN-γ.
Where is CXCL10 produced?
The chemokine CXCL10 was originally identified as an IFN-γ–inducible protein, produced by many cell types in inflamed or infected tissue, such as keratinocytes, macrophages, fibroblasts, and endothelial cells (3). Activated T cells can also produce CXCL10, both in mouse (4) and human (5).
What is the role of CXC chemokine ligand 9?
Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as monokine induced by gamma interferon (MIG). The CXCL9 is one of the chemokine which plays role to induce chemotaxis, promote differentiation and multiplication of leukocytes, and cause tissue extravasation.
What are the GeneCards for the CXCL9 gene?
GeneCards Summary for CXCL9 Gene CXCL9 (C-X-C Motif Chemokine Ligand 9) is a Protein Coding gene. Diseases associated with CXCL9 include Proliferative Glomerulonephritis and Paracoccidioidomycosis. Among its related pathways are CCR5 Pathway in Macrophages and PEDF Induced Signaling.
Where is CXCL9 located in breast cancer cells?
CXCL9 is localized predominantly in the cytoplasm of breast cancer cells and prostaglandin E2 inhibits cytokine induced CXCL9 secretion. In chronic graft-vs-host disease, increased levels of the Th1-associated chemokines CXCL9, CXCL10, and CXCL11 led to recruitment of CXCR3+ T cells from the peripheral blood into affected tissues.
What is the role of CXCL9 in wound repair?
In addition, CXCL9 has potent angiostatic activity, inhibiting blood vessel growth in wound repair and inhibiting tumor growth and tumor-associated vessel expansion.