What are examples of dihydropyridine calcium channel blockers?
Some examples of dihydropyridines include amlodipine, nifedipine, clevidipine, and felodipine. Non-dihydropyridines such as verapamil and diltiazem bind to L-type calcium channels in the sinoatrial and atrioventricular node, as well as exerting effects in the myocardium and vasculature.
What are the non DHP calcium channel blockers?
Calcium Channel Blockers, Non-dihydropyridine
- Calan.
- Calan SR.
- Cardizem.
- Cardizem CD.
- Cardizem LA.
- Cartia XT.
- Covera HS.
- Dilacor.
What are dihydropyridine calcium channel blockers used for?
Dihydropyridine calcium channel blockers are drugs used to treat high blood pressure and severe angina (chest pain caused by lack of oxygen to the heart muscle). Dihydropyridines are one of the different types of calcium channel blockers; they predominately act on blood vessels with less effect on the heart.
What is the difference between dihydropyridine and non-dihydropyridine calcium channel blockers?
While all approved calcium channel blockers inhibit the L-type calcium channel on cells, they are divided into two major categories based upon their predominant physiologic effects: the dihydropyridines, which are predominantly vasodilators and generally have limited chronotropic and inotropic effects, and the non- …
What are the two types of calcium channel blockers?
There are two distinct chemical classes of CCBs: the dihydropyridines (such as nifedipine and amlodipine) and the nondihydropyridines (diltiazem and verapamil).
Is nicardipine a dihydropyridine?
Nicardipine: a hypotensive dihydropyridine-type calcium antagonist with a peculiar cerebrovascular profile.
What is the difference between dihydropyridine and Nondihydropyridine?
Dihydropyridine (DHP) CCBs tend to be more potent vasodilators than non-dihydropyridine (non-DHP) agents, whereas the latter have more marked negative inotropic effects.
What does non dihydropyridine mean?
Nondihydropyridines are one of the different types of calcium channel blockers; they act mainly on the heart with less effect on blood vessels. They have a greater depressive effect on cardiac conduction and contractility but are less potent vasodilators than other types of calcium channel blockers (dihydropyridines).
Which of the following are common side effects of dihydropyridine calcium channel blockers?
Dihydropyridine CCBs can cause flushing, headache, excessive hypotension, edema and reflex tachycardia. Baroreceptor reflex activation of sympathetic nerves and lack of direct negative cardiac effects can make dihydropyridines a less desirable choice for stable angina than diltiazem, verapamil or beta-blockers.
What is the difference between dihydropyridine and non dihydropyridine?
The dihydropyridines are more vascular selective and the non-dihydropyridines are more myocardial selective and tend to reduce the heart rate. Further important differences are between short- and long-acting forms of the calcium channel antagonists.
What is the difference between DHP and DHP?
How do non dihydropyridine calcium channel blockers work?
Nondihydropyridines work by blocking the calcium channels present in the heart muscle and reduce the influx of calcium into cardiac muscle cells (myocytes), leading to a decrease in the heart rate and contractions of the heart muscle.
What is the name of the calcium channel blocker?
Dihydropyridine (DHP) calcium channel blockers are derived from the molecule dihydropyridine and often used to reduce systemic vascular resistance and arterial pressure.
How are calcium channel blockers used to treat angina?
Having calcium channel blockers inhibit the influx of calcium to the cell results in the relaxation of the vascular smooth muscle (vasodilation) and decreased systemic vascular resistance which lowers blood pressure and arterial pressure, which is a major contributor to chest pain (angina) [23].
What are the different types of calcium antagonists?
Several types of calcium antagonists (CA) (verapamil, diltiazem, nifedipine and related drugs) may be used as antihypertensives. In practice, the dihydropyridines (nifedipine and related drugs) are the CA used most frequently as antihypertensives.
Which is calcium channel blockers worsen proteinuria?
Dihydropyridine calcium channel blockers can worsen proteinuria in patients with nephropathy. This CCB class is easily identified by the suffix “-dipine”. Amlodipine (Norvasc) Aranidipine (Sapresta) Azelnidipine (Calblock) Barnidipine (HypoCa) Benidipine (Coniel) Cilnidipine (Atelec, Cinalong, Siscard) Not available in US.