What is micronization in pharmaceutical industry?
Micronization is the process of reducing the particle size of liquid pharmaceutical products using dynamic high pressure homogenization, to make a dispersion of the active ingredients much more stable for enhanced clinical effectiveness.
What is the difference between milling and micronization?
Using physical components to reduce the size of a given compound is called milling. Micronization means micronizing or reducing the size, whereas milling means crushing the particles for reducing their diameter. One can reduce the size of the particle by using milling in the range of micrometer and nanometer.
How does micronization work?
Micronization is the process of reducing the average diameter of a solid material’s particles. The term micronization usually refers to the reduction of average particle diameters to the micrometer range, but can also describe further reduction to the nanometer scale.
What will be the particle size after micronization of drugs?
When a drug is said to be micronized, that means its particle size is generally less than 50 microns. When an API is micronized, its particle size is about 4 to 10 times smaller than conventional drug particles.
What is micronization API?
Micronization is a process for reducing the diameter of a solid material’s particles to enable the solubility of Active Pharmaceutical Ingredients (APIs). Whether administered orally or topically, this solubility is a key factor in bioavailability, and ultimately, the effectiveness of a drug.
What is Micronizer?
The Micronizer is a jet mill (fluid energy mill) employing compressed air or gas to produce particles less than one micron. Precisely aligned jets create a vortex inside the Micronizer. Material is fed into this vortex along an engineered tangent circle and accelerates at near super-sonic speeds.
What are nano suspensions?
Nanosuspension consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion. Preparation of nanosuspension is simple and applicable to all drugs which are water insoluble.
What is milling Pharma?
Milling involves the application of mechanical energy to physically break down coarse particles to finer ones and is regarded as a “top–down” approach in the production of fine particles. Fine drug particulates are especially desired in formulations designed for parenteral, respiratory and transdermal use.
What is the meaning of Micronizer?
A special type of dry-grinding machine in which micronized mica is produced. It consists of a disintegrator that has no moving parts but depends on jets of high-pressure superheated steam for reducing the mica to micrometer sizes.
What is the difference between micronized and nanoparticles?
Nanoparticles are particles defined as less than 100 nanometers in diameter, or 0.1 micron. Typically micronized particles are between 0.1 micron and 100 microns, however the grinding process may result in nanoparticles called ‘fines’ which are smaller and in the nanoparticle range.
What is micronized used for?
Progesterone (Micronized) (Oral) Progesterone is a female hormone important for the regulation of ovulation and menstruation. Progesterone is used to cause menstrual periods in women who have not yet reached menopause but are not having periods due to a lack of progesterone in the body.
Which type of mill is used in Micronisation of drugs?
Micronization can be performed with a jet mill or bead mill.