What is sclerosing stromal tumor?
Sclerosing stromal tumors are an uncommon type of benign ovarian sex cord-stromal tumor. Histologically, they are characterized by a cellular pseudolobular pattern, composed of fibroblasts and round cells separated by densely collagenous or markedly edematous hypocellular tissue and prominent vascularity.
What is a stromal tumor of the ovary?
Ovarian stromal tumors develop in the ovaries’ structural connective tissue cells that produce the female hormones estrogen and progesterone. Stromal cells are among the three most common cell types to be affected by ovarian cancer; however, stromal tumors represent only about 1% of all ovarian cancers.
Are ovarian stromal tumors malignant?
Malignant ovarian stromal tumors are rare and represent approximately 1.2% of all primary malignant ovarian tumors.
How are stromal cell tumors treated?
These cancers are treated with surgery to remove the ovary with the tumor. Surgery is also used to stage and debulk the cancer, as needed. This may be followed by chemo or hormone therapy. Often, the chemo used is the same type used to treat germ cell tumors (PEB: cisplatin, etoposide, and bleomycin).
What is cellular fibroma?
The cellular fibroma is a tumor of uncertain malignant potential that may recur or be associated with peritoneal implants. Usually these are solid tumors, sometimes with small areas of cystic degeneration.
What is ovarian Fibrothecoma?
Ovarian fibrothecoma is a rare, benign, sex cord-stromal neoplasm, with a typically unilateral location in the ovary, characterized by mixed features of both fibroma and thecoma. Patients may be asymptomatic or may present with pelvic/abdominal pain and/or distension and, occasionally, with post-menopausal bleeding.
Does size of ovarian tumor matter?
When it comes to ovarian cancer, size doesn’t necessarily matter: Smaller tumors are just as likely to be malignant. Unfortunately, symptoms of ovarian cancer are vague, causing women to delay seeking care.
Where are stromal cells located?
bone marrow
It is well known that stromal cells arise and are stored in the bone marrow until maturation and differentiation. They are located in the stroma and aid hematopoietic cells in forming the elements of the blood.
Is gist hereditary?
Inheriting certain genetic syndromes. Most GISTs are sporadic (not inherited) and have no clear cause. In rare cases, though, GISTs have been found in several members of the same family. These family members have inherited a gene mutation (change) that can lead to GISTs.
What is echogenic stroma in ovary?
Since the widespread use of transvaginal ultrasound to diagnose polycystic ovary syndrome (PCOS), a cardinal feature has been shown to be the presence of a bright, highly echogenic stroma. Ovarian volume, stromal volume, and stromal peak blood flow velocity were all significantly higher in ovaries from women with PCOS.
What is Stroma cancer?
The stroma is a synonym for the extra-cellular environment. It is present in normal and cancerous tissues. Cancerous tissue comprises two components: cancerous cells and the stroma. The stroma is non-cancerous tissue present in all types of invasive cancers (except leukaemia).
What is the stroma of the ovary?
Stroma of ovary. The stroma of the ovary is a unique type of connective tissue abundantly supplied with blood vessels, consisting for the most part of spindle-shaped stroma cells.
What is ovarian stroma?
Ovarian Stroma. Definition – What does Ovarian Stroma mean? The ovarian stroma is the substance of the ovary—a connective tissue that binds structures together and is enriched with blood vessels, cells, and several hundred thousand follicles.