What does CDC6 and CDT1 do?

What does CDC6 and CDT1 do?

CDC6 is an ATP binding protein and a member of the pre-replicative complex (pre-RC) together with the origin recognition complex (ORC), Cdt1 and the MCM complex (containing MCM2-7p). CDC6 assembles after ORC in an ATP dependent manner and is required for loading MCM proteins onto the DNA.

Where is CDC6 located?

Actually, CDC6 is conserved in every eukaryotic organism, and CDC6-related genes are found in Archaea (14). The human CDC6 gene is located at chromosome 17q21. 3 and its expression is controlled by the E2F/retinoblastoma transcription factors that regulate S-phase-promoting genes (15–17).

Is CDC6 an enzyme?

However, the mutant Cdc6 enzymes remain stuck to the complex, which blocks DNA copying. In cells, if the mutant Cdc6 enzymes are deliberately destroyed after the MCM complex binds to DNA, DNA copying proceeds normally. This implies that Cdc6 inhibits MCM activity as long it remains bound to the complex.

What does CDT1 stand for?

CDT1 (Chromatin Licensing And DNA Replication Factor 1) is a Protein Coding gene. Diseases associated with CDT1 include Meier-Gorlin Syndrome 4 and Meier-Gorlin Syndrome 1. Among its related pathways are Cell cycle Role of SCF complex in cell cycle regulation and CDK-mediated phosphorylation and removal of Cdc6.

Is CDC6 a protein?

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene. The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication.

Is CDC6 a transcription factor?

The human CDC6 gene is located at chromosome 17q21. 3 and its expression is controlled by the E2F family of transcription factors that regulate S-phase-promoting genes.

Is Cdc6 a protein?

What happens when Cdc6 is phosphorylated?

Cdc6 is phosphorylated by cyclin-Cdk1 to promote its degradation after origin firing to prevent DNA rereplication. We previously showed that a yeast GSK-3 homologue, Mck1 kinase, promotes Cdc6 degradation in a SCFCdc4-dependent manner, therefore preventing rereplication.

Is Cdc6 degraded?

Cdc6 is an unstable protein that is rapidly degraded at the G1 to S phase transition (Piatti et al., 1996; Drury et al., 1997; Sánchez et al., 1999) and that must be synthesized de novo in each cell cycle.

How big is the protein of the CDC6 gene?

Protein details for CDC6 Gene (UniProtKB/Swiss-Prot) Protein Symbol: Q99741-CDC6_HUMAN. Recommended name: Cell division control protein 6 homolog. Protein Accession: Q99741. Secondary Accessions: Q8TB30. Protein attributes for CDC6 Gene Size: 560 amino acids. Molecular mass: 62720 Da.

What is the gene for cell division control protein 6?

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.

Where is Cdc6 located in the cell cycle?

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in the cell nucleus during cell cycle phase G1, but translocates to the cytoplasm at the start of S phase.

What kind of diseases are associated with CDC6?

CDC6 (Cell Division Cycle 6) is a Protein Coding gene. Diseases associated with CDC6 include Meier-Gorlin Syndrome 5 and Meier-Gorlin Syndrome 1.