What mutation causes systemic lupus?

Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by Oishi et al., 2008). An autosomal recessive form of systemic lupus erythematosus (SLEB16; 614420) is caused by mutation in the DNASE1L3 gene (602244) on chromosome 3p14. 3.

What is the genetic code for lupus?

No single gene or group of genes has been proven to cause lupus. Lupus does, however, appear in certain families, and when one of two identical twins has lupus, there is an increased chance that the other twin will also develop the disease.

What genes are involved in systemic lupus erythematosus?

Learn more about the genes associated with Systemic lupus erythematosus

IRF5.
NCF2.
PTPN22.
STAT4.
TREX1.

What are the 3 overall causes of lupus?

While the environmental elements that can trigger lupus and cause flares aren’t fully known, the most commonly cited are ultraviolet light (UVA and UVB); infections (including the effects of the Epstein-Barr virus), and exposure to silica dust in agricultural or industrial settings.

What cause lupus flare ups?

What are some triggers for lupus flares?

Overwork and not enough rest.
Stress.
Being out in the sun or having close exposure to fluorescent or halogen light.
Infection.
Injury.
Stopping your lupus medicines.
Other types of medicines.

What is the difference between lupus and systemic lupus?

When people use the term “lupus,” they usually refer to systemic lupus erythematosus, or “SLE.” Throughout this website, the term “lupus” is used to signal systemic lupus, since SLE constitutes the most common form of the disease. Systemic lupus is so-named because it affects many different organ systems in the body.