Is Hes1 a transcription factor?
Transcription factor HES1 (hairy and enhancer of split-1) is a protein that is encoded by the Hes1 gene, and is the mammalian homolog of the hairy gene in Drosophila. It is a transcriptional repressor of genes that require a bHLH protein for their transcription.
What does Hes1 do?
Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability.
What protein activates gene transcription?
Activator protein binding is thought to cause DNA to loop out, bringing the activator protein into physical proximity with RNA polymerase and the other proteins in the complex that promote the initiation of transcription (Figure 4).
What is KLF4 gene?
KLF4 (Kruppel Like Factor 4) is a Protein Coding gene. Diseases associated with KLF4 include Secretory Meningioma and Cerebral Cavernous Malformations. Among its related pathways are Peptide hormone metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
What does myc gene stand for?
MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement.
What are activators and repressors?
Transcription factors that are activators boost a gene’s transcription. Repressors decrease transcription. Groups of transcription factor binding sites called enhancers and silencers can turn a gene on/off in specific parts of the body.
What is an activator in gene expression?
A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur.
What protein does KLF4 code for?
In humans, the protein is 513 amino acids, with a predicted molecular weight of approximately 55kDa, and is encoded by the KLF4 gene. The KLF4 gene is conserved in chimpanzee, rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog….KLF4.
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Is Sox2 a protein?
Sox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This protein family shares highly conserved DNA binding domains known as HMG (High-mobility group) box domains containing approximately 80 amino acids.
How does MYC gene work?
Myc is thought to function by upregulating transcript elongation of actively transcribed genes through the recruitment of transcriptional elongation factors. It can also act as a transcriptional repressor.
Is MYC a tumor suppressor gene?
The tumor suppressor p53 negatively regulates a number of genes, including the proto-oncogene c-Myc, in addition to activating many other genes. One mechanism of the p53-mediated c-Myc repression may involve transcriptional regulation.
Do repressors bind to DNA?
A repressor is a protein that has a negative effect on gene expression. So these usually are proteins that bind to DNA, and they either prevent the RNA transcription machinery from getting in there and transcribing that DNA, or they just slow it down.
What is the function of the Hes1 gene?
HES1 is one of the seven members of the Hes gene family (HES1-7). Hes genes code nuclear proteins that suppress transcription. This protein belongs to the basic helix-loop-helix (bHLH) family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription.
What kind of cancer is associated with HES1?
HES1 (Hes Family BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with HES1 include Medulloblastoma and Precursor T-Cell Acute Lymphoblastic Leukemia . Among its related pathways are Gastric cancer and C-MYB transcription factor network .
How is the Hes gene related to bHLH?
Hes genes code nuclear proteins that suppress transcription. This protein belongs to the basic helix-loop-helix (bHLH) family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription.
Which is part of the Hes gene family suppresses transcription?
HES1 is one of the seven members of the Hes gene family (HES1-7). Hes genes code nuclear proteins that suppress transcription. This protein belongs to the basic helix-loop-helix (bHLH) family of transcription factors.