What is platelet adhesion?
When the lining of a blood vessel is altered or damaged, however, platelets do adhere to the injured site. Platelet adhesion is one of the first events in the formation of hemostatic plugs and thrombi, and plays a part in the development of atherosclerotic lesions.
How does platelet adhesion occur?
Platelets contain several unique adhesion molecules that facilitate interaction with endothelium and other platelets. The GPIb-IX-V complex of glycoproteins mediates platelet adhesion through binding of the counter-ligands P-selectin, Von Willebrand factor (vWF), and Mac-1.
What is platelet adhesion and aggregation?
Platelets stop bleeding from damaged blood vessels and initiate repair processes. In platelets, adhesion refers to the attachment of platelets to subendothelium or to other cells, while platelet-platelet “adhesion” is called aggregation to differentiate these processes clearly.
Why is platelet adhesion bad?
Inappropriate platelet adhesion, activation and aggregation promote excessive platelet plug formation. Activated platelets can also provide negatively-charged surfaces that harbor coagulation factors and markedly potentiate cell-based thrombin generation and blood coagulation [1, 2, 19, 20].
What is platelet plug formation?
Next, platelet plug formation involves the activation, aggregation, and adherence of platelets into a plug that serves as a barrier against blood flow. Coagulation involves a complex cascade in which a fibrin mesh is cleaved from fibrinogen.
What molecules trigger platelet activation and adhesion?
Abstract. Upon vascular injury, platelets are activated by adhesion to adhesive proteins, such as von Willebrand factor and collagen, or by soluble platelet agonists, such as ADP, thrombin, and thromboxane A2.
Why is platelet adhesion important?
Platelet adhesion is an essential function in response to vascular injury and is generally viewed as the first step during which single platelets bind through specific membrane receptors to cellular and extracellular matrix constituents of the vessel wall and tissues.
What chemicals inhibit platelet adhesion and aggregation?
Adenosine and inosine inhibited platelet aggregation and ATP release stimulated by ADP and collagen. Adenosine and inosine reduced collagen-induced platelet adhesion and aggregate formation under flow.
What is platelet plug formation quizlet?
Platelet plug. When platelets come into contact with parts of a damaged blood vessel, their charcteristics change drastically and they quickly come together to form a mass. First step of platelet plug formation. Platelets contact and stick to parts of a damaged blood vessel, such as collagen fibers.
What is the formation and function of platelet plugs and clots?
A platelet plug is formed, and the external bleeding stops. Next, small molecules, called clotting factors, cause strands of blood-borne materials, called fibrin, to stick together and seal the inside of the wound. Eventually, the cut blood vessel heals and the blood clot dissolves after a few days.
What drug is used to reduce platelet adhesion?
An antiplatelet drug (antiaggregant), also known as a platelet agglutination inhibitor or platelet aggregation inhibitor, is a member of a class of pharmaceuticals that decrease platelet aggregation and inhibit thrombus formation.
What does platelet adhesiveness mean?
Platelet adhesiveness refers to the processes or factors which lead to the adhesion of platelets to other structures. It can be contrasted with platelet aggregation, which refers to the processes or factors which lead to the adhesion of platelets to other platelets. U.S. National Library of Medicine(4.00 / 1 vote)Rate this definition:
What is platelet activation?
Platelet activation is a series of cascading responses which allow blood platelets to react to an injury. Platelets could be thought of as one of the body’s emergency response teams; when a cut or burn occurs, the body sends out a distress signal, and platelets are among the many specialized cells which flock to the site.