What is a good aromatase inhibitor?

What is a good aromatase inhibitor?

Anastrozole, exemestane and letrozole are equally effective and have similar side effects [92,106-109]. However, you may tolerate one drug better than another. For a summary of research studies on aromatase inhibitors and early breast cancer, visit the Breast Cancer Research Studies section.

Is aromatase found in males?

Aromatase is also expressed in the male gonad; however, in contrast to its key role as an endocrine coordinator in females, in males, the paracrine effects of aromatase products are essential for normal spermatogenesis.

What causes high aromatase men?

Rearrangements of genetic material involving the CYP19A1 gene cause aromatase excess syndrome. The CYP19A1 gene provides instructions for making an enzyme called aromatase. This enzyme converts a class of hormones called androgens, which are involved in male sexual development, to different forms of estrogen.

What is the strongest aromatase inhibitor?

Results from an intrapatient crossover study revealed that letrozole (2.5 mg daily) consistently resulted in more potent aromatase inhibition compared with 1.0 mg anastrozole (Geisler et al, 2002).

Why would a man take an estrogen blocker?

One reason people think estrogen blockers are prescribed is to treat swelling of breast tissue in males (gynecomastia), a rare medical condition where a young male grows breast tissue that resembles female breast tissue. This condition is extremely rare in older males, even males on testosterone therapy.

What is the best natural aromatase inhibitor?

Grape seed extract: This extract has been shown to act as an aromatase inhibitor, or estrogen blocker, in postmenopausal women at high risk for breast cancer. Men may experience similar benefits when taking it as a supplement.

What foods are aromatase inhibitors?

The following foods contain compounds that have been shown to inhibit aromatase activity, thereby suppressing estrogen biosynthesis:

• Artichokes.
• Arugula.
• Blueberries & bilberries.
• Broccoli & broccoli sprouts.
• Brussels sprouts.
• Cabbage.
• Cauliflower.
• Celery.

How can a man reduce estrogen?

Control estrogen by…

1. avoiding environmental estrogens, such as parabens in personal care products.
2. losing weight (or, more importantly, body fat)
3. reducing your alcohol intake.
4. adding cruciferous vegetables (like broccoli) to your diet.

Should I take an estrogen blocker with testosterone?

Given its ability to increase estrogen levels, testosterone replacement therapy may actually throw off your hormonal levels. Thus, it’s crucial to use estrogen blockers when you’re undergoing TRT.

Does anastrozole cause erectile dysfunction?

Although anastrozole has been shown to increase testosterone levels, a recent analysis suggests that it doesn’t lead to improvements in sexual function like erectile function or libido and also doesn’t improve semen quality.

Do estrogen blockers increase testosterone?

Estrogen Blockers Help TRT Achieve Hormonal Balance These blockers may even prevent estrogen receptors from forming–meaning they can help enhance the benefits of testosterone replacement therapy by ensuring the body achieves the optimal hormonal balance.

Are there any natural aromatase inhibitors for men?

If you only add one natural aromatase inhibitor for men into your routine, make it zinc. It carries a powerful one-two punch that increases testosterone production and reduces testosterone conversion. Sometimes your mom was right.

Why are aromatase inhibitors used in obese men?

The second place where aromatase inhibitors are used are in men who naturally have too little testosterone while making too much estrogen. This is most common in obese men as the aromastase enzyme that converts testosterone into estrogen is found in high concentrations in fat or adipose tissue.

How does anastrozole affect testosterone levels in older men?

A small, controlled study demonstrated that anastrozole in a dose of 1 mg daily during 12 weeks will result in doubling of the mean bioavailable testosterone level in older men. A more recent study also showed a moderate but significant effect of aromatase inhibition on estradiol and testosterone levels in older men.

How does aromatase inhibit testosterone in the body?

Aromatization threatens that balance. The key to keeping aromatization in line is to inhibit the presence of aromatase in your body. As the name suggests, this enzyme is the key ingredient in the aromatization recipe that turns testosterone into estradiol. Less aromatase = less testosterone conversion = more testosterone for your body.