What is the importance of heterocyclic compounds?
Heterocyclic compunds have a wide range of application. They are predominantly used as pharmaceuticals, as agrochemicals and as veterinary products. They also find applications as sanitizers, developers, antioxidants, as corrosion inhibitors, as copolymers, dye stuff.
What are two of the products that are useful in medicinal chemistry?
Pharmaceutical biotechnology is a recent area of medicinal chemistry, producing new therapeutic and diagnostic products. The common products are peptides and proteins, hormones of different origins, and enzymes, including vaccines and monoclonal antibodies (Table 3).
What is the importance of medicinal chemistry?
Medicinal chemistry provides pharmacy students with a thorough understanding of drug mechanisms of action, structure-activity relationships (SAR), acid-base and physicochemical properties, and absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles.
Why heterocyclic compounds are important scaffolds in medicinal chemistry?
Many heterocyclic scaffolds can be considered as privilege structures. Thus, heterocycles have critical importance for medicinal chemists, because using them, it is possible to expand the available drug-like chemical space and drive more effective drug discovery programs.
What do you understand by heterocyclic compounds?
heterocyclic compound, also called heterocycle, any of a major class of organic chemical compounds characterized by the fact that some or all of the atoms in their molecules are joined in rings containing at least one atom of an element other than carbon (C).
What is the use of benzimidazole *?
Abstract:Benzimidazole and its derivatives are regarded as an important heterocyclic motif that exhibits a wide range of pharmaceutical applications including anticancers, antihypertensives, antivirals, antifungals, anti-HIVs, anti-convulsants, and anti-diabetics.
What is benzimidazole used for?
The benzimidazoles are a large chemical family used to treat nematode and trematode infections in domestic animals. They also have limited activity against cestodes.
What is the role of chemistry in the production of promising medicinal products?
Computational chemistry is a speciality that contributes to the design of drugs as well as the drug discovery process by helping to design and study molecular structures and chemical compounds that are used as the foundation of new medicines.
What is meant by lead compounds in medicinal chemistry?
In medicine, a chemical compound that shows promise as a treatment for a disease and may lead to the development of a new drug. Once a lead compound has been found, the chemical structure is used as a starting point to make a drug that has the most benefits and the least harms.
What roles do medicinal chemists play in discovering and developing new drugs?
Medicinal chemists prepare and/or select appropriate compounds for biological evaluation that, if found to be active, could serve as LEAD COMPOUNDS. They then evaluate the STRUCTURE–ACTIVITY RELATIONSHIPS (SARs) of analogous compounds with regard to their in vitro and in vivo efficacy and safety.
What is heterocyclic compound with example?
The most common heterocycles are those having five- or six-membered rings and containing heteroatoms of nitrogen (N), oxygen (O), or sulfur (S). The best known of the simple heterocyclic compounds are pyridine, pyrrole, furan, and thiophene.