What are the 7 steps of the life cycle of the flavivirus?
The basic stages of the flavivirus life cycle include attachment to the cell surface, internalization into the host cell, transfer of the viral RNA genome into the cytoplasm, translation of the viral proteins, replication of the genomic RNA, assembly and maturation of the virions, and ultimately the release of progeny …
What causes Flaviviridae?
Infection with this flavivirus is caused by the bites of mosquitoes (Aedes aegypti and Aedes albopictus). However, the virus can also be transmitted by semen, blood transfusion and possibly saliva and breastfeeding, but this has not been confirmed so far.
Is Flaviviridae a retrovirus?
Retrovirus. RNA viruses such as retroviruses, lentiviruses, alphaviruses, flaviviruses, rhabdoviruses, measles viruses, Newcastle disease viruses, and picornaviruses have so far been engineered to be used as gene transfer vector for the treatment of a variety of diseases [32].
How many flaviviruses are there?
Flaviviruses are the most prevalent arthropod-borne viruses worldwide, and nearly half of the 70 Flavivirus members identified are human pathogens. Despite the huge clinical impact of flaviviruses, there is no specific human antiviral therapy available to treat infection with any of the flaviviruses.
How does Flavivirus reproduce?
Replication of Flaviviruses takes place in the cytoplasm. Flavivirus cannot replicate in the nucleus because, like most other RNA viruses, it uses the host cell’s RNA dependant RNA polymerase to replicate. Primarily, the virus will make a full length copy of the complementary, minus strand genome.
What are the symptoms of Flavivirus?
What are the symptoms of Flaviviridae? General symptoms include fever, body aches, headache, and joint pain. Some of these illness may also cause vomiting and diarrhea. The diseases caused by Flaviviridae viruses can be fatal.
How is flaviviridae transmitted?
A flavivirus is transmitted via the bite of an infected tick or mosquito. It enters the bloodstream and invades and infects cells called monocytes in the immune system. The virus is then transported to lymph nodes and targets organs within the body, where different flaviviruses cause different symptoms.
Which of the following viruses belong to family Flaviviridae?
Members of this family belong to a single genus, Flavivirus, and cause widespread morbidity and mortality throughout the world. Some of the mosquitoes-transmitted viruses include: Yellow Fever, Dengue Fever, Japanese encephalitis, West Nile viruses, and Zika virus.
What viruses are in the Flaviviridae family?
What family is Flaviviridae in?
Flaviviridae is a family of enveloped positive-strand RNA viruses which mainly infect mammals and birds….
| Flaviviridae | |
|---|---|
| Order: | Amarillovirales |
| Family: | Flaviviridae |
| Genera | |
| Flavivirus Hepacivirus Pegivirus Pestivirus |
What family is flaviviridae in?
Why is Flavivirus significant?
The flavivirus genus encompasses more than 75 unique viruses, including dengue virus which accounts for almost 390 million global infections annually. Flavivirus infection can result in a myriad of symptoms ranging from mild rash and flu-like symptoms, to severe encephalitis and even hemorrhagic fever.
How many viruses are in the family Flaviviridae?
Flaviviridae has a total of 69 pathogens in its rank. The family gets its name from Yellow Fever virus, a type virus of Flaviviridae; flavus means yellow in Latin. The Flavivirus genus contains several nasty critters that include yellow fever virus, dengue fever virus, and Japanese encephalitis (JE) virus.
Can a Flaviviridae virus survive in a tick?
Many species of Flaviviridae can replicate in both mammalian and insect cells. They can survive for long periods in hosts such as ticks by replicating in this host without damage to the insect. Flaviviridae viruses produce a wide range of diseases including fever, arthralgia, rash, haemorrhagic fever and encephalitis.
How big are the capsids of Flavivirus?
The capsids are approximately 40-50 nanometers in diameter and are composed of a single type of capsid protein. Unlike cellular mRNA, the genome of Flavivirus lacks a poly-A tail. However, a type I cap does sit on the 5’ end and type II caps have been found in the RNA of infected cells.
Where are structural genes located in a flavivirus?
In Flaviviruses structural genes are found at the 5’ of the genome and non-structural genes are encoded at the 3’ end of the genome. This organization allows the virus to maximize production of structural genes, since viral assembly requires more structural proteins to be made than non-structural proteins.