How non aqueous solvents are classified?
Inorganic nonaqueous solvents can be classified into two groups, protic solvents and aprotic solvents. Early studies on inorganic nonaqueous solvents evaluated ammonia, hydrogen fluoride, sulfuric acid, as well as more specialized solvents, hydrazine, and selenium oxychloride.
What is non aqueous solution in pharmacy?
Non-aqueous solvents Non-aqueous solvent systems are used when the drug is insufficiently soluble or stable in aqueous systems, or when a solution is intended for specific properties, such as sustained drug absorption.
What are the types of solvents used in non aqueous titration?
Types of non-aqueous solvents used in non-aqueous titration
- Aprotic Solvents.
- Protophilic Solvents.
- Protogenic Solvents.
- Amphiprotic Solvents.
What are the different non aqueous solutions?
Common examples are liquid ammonia, liquid sulfur dioxide, sulfuryl chloride and sulfuryl chloride fluoride, phosphoryl chloride, dinitrogen tetroxide, antimony trichloride, bromine pentafluoride, hydrogen fluoride, pure sulfuric acid and other inorganic acids.
Which is an example of non aqueous solvent?
The examples of nonprotonic solvents are bromine trifluoride, sulfur dioxide, dinitrogen tetroxide, and phosphorus oxychloride.
What are non aqueous solvents give an example?
A solution in which water is not the solvent is known as a non-aqueous solution. Solution of sulphur in carbon disulphide, Solution of iodine in carbon tetrachloride and Ethene in dichloromethane are some examples of non-aqueous solutions.
Is syrup an aqueous solution?
Syrup is a nearly saturated aqueous solution of sugar such as sucrose in water, with or without medicinal or flavouring ingredients. When the syrup contains some added medicinal substances, it is called medicated syrup.
What are different types of pharmaceutical solutions?
Types of solutions
- Syrup. Syrup is a saturated sugar solution.
- Elixir. Sweetened hydroalcoholic (combinations of water and ethanol) solutions are termed elixirs.
- Tincture.
- Oil-based solutions.
- Miscellaneous solutions.
- Dry or lyophilized mixtures for solution.
Which drug is assayed by non aqueous titration?
ALKALIMETRY IN NON-AQUEOUS TITRATIONS The wide spectrum of such organic compounds in-clude : anhydrides, acids, amino acids, acid halides, enols (viz., barbiturates), xanthines, sulphonamides, phenols, imides and lastly the organic salts of inorganic acids.
Which indicator is used in non aqueous titration?
indicators used in non aqueous titration. Crystal Violet. 0.5% w/v solution in glacial acetic acid .
How many types of non-aqueous solvents are there?
Typically, there exist four types of solvents used in the non-aqueous titration of a given analyte. These are: Aprotic Solvents – these solvents are neutral in charge and are chemically inert. They also generally have a low dielectric constant.
What is non-aqueous?
: not aqueous : of, relating to, or having the characteristics of a liquid other than water a nonaqueous solvent : made from, with, or by means of a liquid other than water nonaqueous solutions.
How are non-aqueous solvents used in pharmaceutical formulations?
Non-aqueous solvents have long been used in subcutaneous or intramuscular pharmaceutical formulations to dissolve water-insoluble drugs. In recent years, the need for these vehicles was increased since the drug discovery process has yielded many poorly water-soluble drugs.
Which is a weak acid in a non aqueous solvent?
•Note, because of the common ion effect, if HCl is dissolved in acetic acid, the extent of ionization is less than in water and HCl acts as a weak acid. •Non-aqueous solvents that are good proton acceptors (e.g. NH 3) enable acids to ionize. •In a basic solvent, all acids are strong.
How are nitrosyl salts classified as non aqueous solvents?
N 2O 4⇌ [NO]+ + [NO 3]- In this solvent medium, nitrosyl salts behave as acids and metal nitrates (MNO 3) act as bases. Non-aqueous solvents that are self-ionizing may be classified as: 1) proton containing (NH
Can a compound behave as an acid in a non aqueous media?
Effect of dissolving an ‘acid’ in acidic non-aqueous solvents enables us to realize that just because a compound is named an ‘acid’, it may not behave as one in non-aqueous media. HNO 3+ 2H 2SO 4 ⇌[NO