Is tenofovir a Nrti?

Today, the most commonly used NRTIs are tenofovir and abacavir, both used in combination of emtricitabine or lamivudine. These agents, along with zidovudine, will be discussed below.

What are the NRTI drugs?

Available NRTIs

zidovudine (Retrovir)
lamivudine (Epivir)
abacavir sulfate (Ziagen)
didanosine (Videx)
delayed-release didanosine (Videx EC)
stavudine (Zerit)
emtricitabine (Emtriva)
tenofovir disoproxil fumarate (Viread)

What is the difference between NRTIs and NNRTIs?

So NRTIs are like another zip giving the zipper another track to follow. NNRTIs work by sitting in a binding site in the virus structure and this is a bit like having an object that blocks the teeth of the zipper, so the zipper cannot get past the block.

What is reverse transcriptase inhibitors examples?

Nucleoside analogue reverse transcriptase inhibitors including didanosine (ddI), lamivudine (3TC), stavudine (d4T), zalcitabine (ddC), and zidovudine (ZDV, formerly AZT) are used to treat human immunodeficiency virus (HIV) infection.

What are the side effects of NRTIs?

NRTIs and Side Effects

Nausea.
Dizziness.
Tiredness.
Stomach problems.
Headache.
Diarrhea.
Trouble sleeping.

What is a common concern when taking epzicom?

Headache, nausea, diarrhea, dizziness, tiredness, or trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Is acyclovir a Nrti?

Acyclovir and the nucleoside reverse transcriptase inhibitors (NRTIs) are incorporated into viral DNA and cause chain termination because they lack the 3′-hydroxyl group required to attach the next nucleoside. Ganciclovir and penciclovir do not cause chain termination.

What do NRTIs do?

NRTIs are one of 6 classes of antiretroviral drugs (ARVs) used to treat HIV as part of antiretroviral therapy (ART). ARVs interfere with the ability of a virus to multiply or reproduce. To treat HIV, NRTIs work by blocking an enzyme HIV needs to make copies of itself.

How do you stop reverse transcriptase?

NNRTIs block reverse transcriptase by binding directly to the enzyme. NNRTIs are not incorporated into the viral DNA like NRTIs, but instead inhibit the movement of protein domains of reverse transcriptase that are needed to carry out the process of DNA synthesis.