Which leukemia increases ICP?

Which leukemia increases ICP?

We present a patient with chronic myeloid leukemia (CML) who had marked bilateral disc swelling as part of his initial presentation. This occurred in the setting of raised intracranial pressure (ICP), with normal cerebrospinal fluid (CSF) composition and cell content, and normal neuroimaging.

Can leukemia cause intracranial hypertension?

The most likely pathogenesis of the elevated ICP in such cases is that the elevated white cell count in leukemia causes hyperviscosity which decreases the absorption of CSF from the arachnoid villi. This results in increased intracranial pressures.

What cells are increased in CML?

Bone marrow is the spongy, red tissue in the inner part of large bones. CML most often causes an increase in the number of white blood cells, such as neutrophils or granulocytes, that normally fight infection. It is also sometimes called chronic granulocytic, chronic myelocytic, or chronic myelogenous leukemia.

Can CML spread to the brain?

Leukemia can spread to the central nervous system (CNS), including the brain and spinal cord.

What happens if leukemia spreads to the brain?

Leukemia cells can spread to the central nervous system and build up in the fluid surrounding the spine and the brain. This can cause symptoms like headaches, seizures, balance problems, and abnormal vision.

Which type of leukemia has frequent CNS involvement?

The CNS involvement is more common in acute lymphocytic leukemia (ALL), than in adult acute myeloid leukemia (AML), although the rates for the second case might be underestimated.

How high are WBC in CML?

In CML, the increase in mature granulocytes and normal lymphocyte counts (low percentage due to dilution in the differential count) results in a total WBC count of 20,000-60,000 cells/μL. A mild increase in basophils and eosinophils is present and becomes more prominent during the transition to acute leukemia..

How does CML cause more granulocytes?

In CML the bone marrow produces too many white cells, called granulocytes. These cells (sometimes called blasts or leukaemic blasts) gradually crowd the bone marrow, interfering with normal blood cell production. They also spill out of the bone marrow and circulate around the body in the bloodstream.

Can CML cause seizures?

It is clinically characterized by headache, vomiting, seizures, and focal neurological deficits. Herein, we report a case of CML in blast crisis in a 28-year-old male gradually developing CNS infiltration by blast cells diagnosed by cerebrospinal fluid (CSF) cytology.

Can CML metastasize?

Typically, being categorized as chronic indicates that this type of leukemia spreads and grows slowly. However, CML can change from slow progressing into a rapidly growing, acute form of leukemia that can spread to almost any organ in the body.

Does AML affect the brain?

In general, all organs can potentially be affected by AML. If AML spreads to the brain and its meninges, patients may suffer from headache, visual disturbances, nausea, vomiting, and other central nervous system impairments.