What does Dectin-1 do?

What does Dectin-1 do?

Dectin-1 detects fungal β-glucans (specifically β-1,3-glucans) and plays key roles in immune defense against fungi such as Candida albicans and Aspergillus fumigatus (Drummond and Brown, 2011; Goodridge et al., 2009). β-Glucans are large polymers of d-glucose and are a major structural component of fungal cell walls.

Is Dectin-1 a phagocytic receptor?

Dectin-1 is a key phagocytic receptor for fungi and triggers a massive oxidative burst in response to fungal exposure5,6,10,11. TLRs sense soluble microbial stimuli and are activated by dimerization of intracellular signalling domains.

What are Dectin receptors?

Dectin-1 is a natural killer (NK)-cell-receptor-like C-type lectin that is thought to be involved in innate immune responses to fungal pathogens. This transmembrane signalling receptor mediates various cellular functions, from fungal binding, uptake and killing, to inducing the production of cytokines and chemokines.

Is Dectin 1 a pattern recognition receptor?

Dectin-1 is a mainly myeloid-cell-expressed NK-cell-receptor-like C-type lectin that functions as a transmembrane pattern-recognition receptor through its ability to bind β-glucan carbohydrates. Dectin-1 can recognize several fungal pathogens and might play a role in the innate response to these organisms.

Is beta glucan a prebiotic or probiotic?

Cereal beta-glucans have been demonstrated to have prebiotic properties owing to their ability to pass undigested through the gastro-intestinal tract (GIT), where they act as a substrate for microbial fermentation and selectively stimulate the growth and activity of a small number of beneficial bacteria (Gibson, 2004).

Does beta glucan raise blood sugar?

Beta-glucans have been tested to be effective in lowing blood glucose concentrations and decreasing hyerlipidemia and hypertension (Kim et al 2005; Goff et al 2007).

How does beta-glucan help immune system?

Once they are in the immune system, researchers believe beta glucans: Enhance immune activation, which translates into anti-cancer activity. Spur immune cells to produce anti-cancer compounds called cytokines, which regulate inflammation and help the immune system fight diseases such as cancer.

What kind of infections can Dectin-1 deficiency cause?

Human dectin-1 Deficiency and Mucocutaneous Fungal Infections – PubMed Mucocutaneous fungal infections are typically found in patients who have no known immune defects.

How is the expression of dectin-1 determined?

Dectin-1 expression was determined by means of flow cytometry with the use of a fluorescence-activated cell sorter (FACSCalibur, BD Biosciences).

What is the role of Dectin 1 in fungal infection?

Dectin-1 is a primary and well-studied C-type lectin receptor (CLR) that is primarily responsible for β-glucan recognition and control of fungal infection ( Ferwerda et al., 2010; Taylor et al., 2007 ).

Where is the Dectin-1 mutation located on the chromosome?

Dectin-1 Mutation in a Family with Mucocutaneous Fungal Infections. Panel A shows the structure of the dectin-1 gene and the location of an early-stop-codon mutation consisting of a homozygous single-nucleotide polymorphism (rs16910526, exon 6, chromosome 12; location, 10162354 bp).