What does the ATF3 gene do?
ATF3 functions as an oncogene or tumor suppressor in prostate cancer. ATF3 may be upregulated by androgen, thus induces cell proliferation and G1-to-S-phase transition of the cell cycle. In addition, ATF3 SUMOylation enhanced cyclin D1 (CCND1) activation, resulting in increased cell proliferation and colony formation.
What is ATF4 gene?
ATF4 (Activating Transcription Factor 4) is a Protein Coding gene. Diseases associated with ATF4 include Coffin-Lowry Syndrome and Leukoencephalopathy With Vanishing White Matter. Among its related pathways are CNTF Signaling and DREAM Repression and Dynorphin Expression.
Where is ATF3 located?
the nucleus
ATF3 proteins are localized in the nucleus. ATF3 is a member of the CREB/ATF family of transcription factors and both homodimerize and heterodimerize with other members of CREB/ATF family, including C/EBPg, CHOP/DDIT3, ATF2, Jun, JunB, p21SNFT/JDP1, and Nrf2/NFE2L2.
What type of compound is ATF5?
ATF5 (Activating Transcription Factor 5) is a Protein Coding gene.
How is ATF4 regulated?
ATF4 expression is regulated transcriptionally and translationally by the PERK pathway, which involves the phosphorylation of eIF2α, and post-translationally by phosphorylation, which targets ATF4 for proteasomal degradation [5]. Previous studies have demonstrated that ATF4 is involved in oncogenic process.
What is ATF3 in biology?
Network analysis predicted that ATF3 is part of a transcriptional complex that also contains members of the nuclear factor (NF)-kappaB family of transcription factors. ATF3 seems to inhibit Il6 and Il12b transcription by altering chromatin structure, thereby restricting access to transcription factors.
What diseases does the endoplasmic reticulum cause?
There is accumulating evidence implicating prolonged ER stress in the development and progression of many diseases, including neurodegeneration, atherosclerosis, type 2 diabetes, liver disease, and cancer.
What happens if the endoplasmic reticulum malfunctions?
A malfunction of the ER stress response caused by aging, genetic mutations, or environmental factors can result in various diseases such as diabetes, inflammation, and neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, and bipolar disorder, which are collectively known as ‘conformational …
Is chop a protein?
CHOP is a 29 kDa protein with 169 (human) or 168 (rodents) amino-acid residues. CHOP protein was first identified to be a member of the CCAAT/enhancer binding proteins (C/EBPs) that serves as a dominant negative inhibitor of C/EBPs.
What does ATF4 mean?
Activating transcription factor 4
Activating transcription factor 4 (tax-responsive enhancer element B67), also known as ATF4, is a protein that in humans is encoded by the ATF4 gene.
What is ATF +3?
Kendall ATF+3™ is specifically designed for use in automatic transmissions and transaxles in most Chrysler vehicles built from 1988 through 1999 and some later models. It is formulated to provide optimum performance in Chrysler automatic transmissions equipped with lock-up torque converters.
How does GOLPH3 affect the development of prostate cancer?
GOLPH3 overexpression may participate in the occurrence and development of colorectal carcinoma by inhibiting apoptosis and promoting angiogenesis. Results show that high GOLPH3 and nuclear/cytoplasmic YB-1 expression correlated with a poor prognosis in patients with prostate cancer.
How is Golgi phosphoprotein 3 related to POMGnT1?
Data indicate that Golgi phosphoprotein 3 (GOLPH3) binds to and controls the Golgi localization of protein O-linked mannose beta-1,2-N-acetlyglucosaminyltransferase 1 (POMGnT1). GOLPH3 is associated with prognosis in colorectal cancer patients treated with postoperative 5-fluorouracil-based adjuvant chemotherapy.
How is GOLPH3 expression related to breast cancer?
High GOLPH3 expression is associated with breast cancer. This study provides a brand new evidence that GOLPH3 promotes glioma cell proliferation by facilitating Wls recycling and Wnt/beta-catenin signaling. High GOLPH3 expression is associated with glioma progression.
Who is Gene Simmons and what is his real name?
For other uses, see Gene Simmons (disambiguation). Not to be confused with Jean Simmons. Gene Simmons (born Chaim Witz August 25, 1949), is an American musician, singer, and songwriter.