What CD138 positive?
Various types of epithelial cells are also CD138 positive. Squamous epithelial cells show strong membranous and some cytoplasmic staining, except for the mature superficial squamous epithelial cells which are unstained. Mature mesenchymal tissues are not stained.
What does CD138 positive plasma cells mean?
CD138 is a classic plasma cell marker and can be found on both normal polyclonal or abnormal monoclonal plasma cells. Being CD138 positive and knowing the total plasma cell % from the core bone specimin would be the best markers to understand the extent of bone marrow infiltration.
Where is CD138 expressed?
In normal tissues, CD138 is known to be expressed on plasma cells and various epithelial cell types.
What is CD138 marker?
During normal B-cell development, cells acquire expression of CD138, also known as syndecan-1 (SDC1), a marker highly specific for terminally differentiated normal plasma cells (1). CD138 is a heparin sulphate proteoglycan that controls tumor cell survival, growth, adhesion and bone cell differentiation in MM (2).
What is CD38 and CD138?
Abstract. Background/Aim: CD38 is a cell surface marker commonly present in plasma cells and activated T cells, while CD138 is a representative plasma cell marker.
What does CD138 negative mean?
Endometrial CD138 count appears to be a negative prognostic indicator for patients who have experienced previous embryo transfer failure – Fertility and Sterility.
Do T cells express CD138?
Similar to C3H gld mice, a large population of CD138-expressing T cells accumulate in peripheral organs of Fas receptor mutant μMT/Lpr, B6/Lpr (25) and MRL/Lpr mice (Figure 1A). As previously described, the majority of CD138+ T cells also express CD3 and B220 and are negative for CD4 and CD8 (dnT).
How is CD138 expression related to tumor prognosis?
The expression of CD138 in predicting of tumor behavior varies with tumor type and differentiation grade. The expression is reduced in squamous cell carcinogenesis and low level of expression correlates with poor prognosis in head and neck carcinomas and squamous cells carcinoma of uterine cervix.
What do you need to know about the CD138 test?
What is CD138 Test? CD138 is a protein present on plasma cells in the bone marrow, and on certain epithelial cells. The protein is useful to diagnose any neoplasms (tumors) growing in plasma cells. If a patient is to be tested for cancer, CD138 stains can be used to spot tumor cells.
Where is CD138 found in the bone marrow?
CD138 is a protein present on plasma cells in the bone marrow, and on certain epithelial cells. The protein is useful to diagnose any neoplasms (tumors) growing in plasma cells.
Is there a reactivity for CD138 in mesothelioma?
The reactivity for CD138 is only rarely seen in malignant mesothelioma though staining in epithelioid variants has been reported. Among mesenchymal tumors, synovial sarcoma show strong positive staining for CD138 in cell membrane and cytoplasm in glandular areas of biphasic type and weaker in cytoplasm in spindle cell areas (mAb clone B-B4).