How is lovastatin manufactured?
Commercially lovastatin is produced by a variety of filamentous fungi including Penicillium species, Monascus ruber and Aspergillus terreus as a secondary metabolite. Production of lovastatin by fermentation decreases the production cost compared to costs of chemical synthesis.
What is lovastatin and what is the mechanism of its action?
Lovastatin is in a class of medications called HMG CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.
What is the meaning of lovastatin?
(LOH-vuh-STA-tin) A drug used to lower the amount of cholesterol in the blood. It is also being studied in the prevention and treatment of some types of cancer. Lovastatin is a type of HMG-CoA reductase inhibitor (statin). Also called Mevacor.
What is the meaning of HMG CoA reductase inhibitors?
A substance that blocks an enzyme needed by the body to make cholesterol and lowers the amount of cholesterol in the blood. HMG-CoA reductase inhibitor drugs are called statins.
Who is the manufacturer of lovastatin?
Lovastatin manufacturers | traders | suppliers Shandong Octagon Chemicals Limited from China. Lupin from India. Concord Biotech from India. Sterling Biotech from India.
What is the chemical name of lovastatin?
Lovastatin acid
| PubChem CID | 64727 |
|---|---|
| Structure | Find Similar Structures |
| Molecular Formula | C24H38O6 |
| Synonyms | Lovastatin acid Mevinolinic acid Monacolinic K acid MSD 803 acid UNII-5CLV35Y90C More… |
| Molecular Weight | 422.6 |
What is the active form of lovastatin?
beta-hydroxy acid
Lovastatin is metabolized into its active form beta-hydroxy acid in the stomach and functions to competitively inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme is involved in the rate-limiting step of cholesterol synthesis.
What is the brand name for lovastatin?
Lovastatin oral tablet is available as a brand-name drug and a generic drug. Brand name: Altoprev. Lovastatin oral tablet comes in two forms: immediate-release tablet and extended-release tablet. Lovastatin is used to prevent and treat coronary heart disease.
How do statins block HMG-CoA reductase?
Statins act by competitively binding to the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase, HMGCR)8,9 and blocking the conversion of HMG-CoA to mevalonate, the rate-limiting step of cholesterol biosynthesis.
Why do statins target HMG-CoA reductase?
Statins work by competitively blocking the active site of the first and key rate-limiting enzyme in the mevalonate pathway, HMG-CoA reductase. Inhibition of this site prevents substrate access, thereby blocking the conversion of HMG-CoA to mevalonic acid.
Where does the biosynthesis of lovastatin take place?
The biosynthesis of lovastatin occurs via an iterative type I polyketide synthase (PKS) pathway. The six genes that encode enzymes that are essential for the biosynthesis of lovastatin are lovB, lovC, lovA, lovD, lovG, and lovF . The synthesis of dihydromonacolin L requires a total of 9-malonyl Coa .
How is Lovastatin used to lower blood cholesterol?
lovastatin – an oral drug (trade name Mevacor) to reduce blood cholesterol levels; used when dietary changes have proved inadequate. Mevacor. lipid-lowering medication, lipid-lowering medicine, statin, statin drug – a medicine that lowers blood cholesterol levels by inhibiting HMG-CoA reductase.
How does lovastatin interfere with the production of mevalonate?
Mevalonate is a required building block for cholesterol biosynthesis and lovastatin interferes with its production by acting as a reversible competitive inhibitor for HMG-CoA, which binds to the HMG-CoA reductase.
Is the structure of lovastatin a man made molecule?
Lovastatin is man-made. It is a 24-carbon molecule with three rings, two ester functionalities with one being a lactone, a pair of conjugated carbon-carbon double bonds, and a hydroxyl group. With an IHD of seven, the empirical formula of lovastatin is C24 H 36 O 5. The structure of lovastatin is shown in Fig. 3.2.1.