What is the function of IL-4?
IL-4 has an important role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. It is produced only by a subset of activated hematopoietic cells, including T cells and Fc epsilon R1+ mast cells and basophils.
What does IL-4 stimulate?
Interleukin 4 has many biological roles, including the stimulation of activated B cell and T cell proliferation, and the differentiation of B cells into plasma cells. It is a key regulator in humoral and adaptive immunity. IL-4 induces B cell class switching to IgE, and up-regulates MHC class II production.
Is IL-4 anti inflammatory?
Interleukin-4 and IL-10 are pleiotropic anti-inflammatory cytokines that function mainly by suppressing the pro-inflammatory milieu. Several different immune cells that produce IL-4 are activated T cells, mast cells, basophils, eosinophils, and NKT cells (21, 22).
Do Th1 cells produce IL-4?
Based on the pattern of the cytokines which they secrete, distinct subsets of effector helper T (Th) cells can be distinguished. Type 1 Th cells (Th1 cells) secrete IL-2, interferon-gamma (IFN-γ) and tumour necrosis factor (TNF), whereas type 2 Th cells (Th2 cells) produce IL-4, IL-5, IL-6 and IL-13.
What does IL-4 do in asthma?
IL-4, produced by T lymphocytes, activated mast cells and basophils, is involved in asthma via its role in many cellular mechanisms such as IgE production, eosinophil chemotaxis and the development of effector T cell responses [72].
What are the anti inflammatory cytokines?
The anti-inflammatory cytokines are a series of immunoregulatory molecules that control the proinflammatory cytokine response. Cytokines act in concert with specific cytokine inhibitors and soluble cytokine receptors to regulate the human immune response.
What are the diseases associated with the IL4 gene?
GeneCards Summary for IL4 Gene IL4 (Interleukin 4) is a Protein Coding gene. Diseases associated with IL4 include Schistosomiasis and Allergic Disease. Among its related pathways are IL-9 Signaling Pathways and PEDF Induced Signaling.
How does IL-4 affect the progression of cancer?
IL-4 has a significant effect on tumor progression. Increased IL-4 production was found in breast, prostate, lung, renal cells and other types of cancer. Many overexpression of IL-4R has been found in many types of cancer. Renal cells and glioblastoma modify 10,000-13,000 receptors per cell depending on tumor type.
Which is a paralog of the IL8 gene?
Gene Ontology (GO) annotations related to this gene include chemokine activity and interleukin-8 receptor binding . An important paralog of this gene is CXCL1. IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes.
Why is IL-4 a type 2 cytokine?
Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury.