What is Noxafil used for?
Posaconazole is used to prevent certain fungal infections in patients who have severely weakened immune systems (such as patients who have had chemotherapy). It belongs to a class of drugs known as azole antifungals. It works by stopping the growth of fungi.
What are the indications for posaconazole?
The European Medicines Agency (EMA) has approved posaconazole for (1) treatment of aspergillosis, fusariosis, chromoblastomycosis, and coccidioidomycosis in patients who are refractory to or intolerant of other azoles or amphotericin B; (2) first-line therapy for OPC for severe disease or in those unlikely to respond …
What is posaconazole used to treat?
Posaconazole is used to prevent serious fungal infections that can spread throughout the body in adults and children 2 years of age and older with a weakened ability to fight infection.
When is posaconazole recommended?
Posaconazole is recommended as prophylaxis drug of choice in patients with AML and myelodysplastic syndrome who have chemotherapy induced neutropenia, and allogeneic HSCT recipients with GVHS (Grade AI recommendation).
How do you use Noxafil?
Take prepared PowderMix with food. Take Noxafil oral suspension during or within 20 minutes after eating a full meal. If you cannot eat a full meal, take the medicine with a nutritional supplement or acidic carbonated drink such as ginger ale.
How long does noxafil stay in your system?
Table 1
| Property | Posaconazole |
|---|---|
| Time to maximum concentration | 4–5 hours |
| Metabolism | Hepatic: glucuronidation to inactive metabolites |
| Elimination half-life | 25–35 hours |
| Elimination route | <1% excreted unchanged in urine; 66% excreted unchanged in feces |
What is the difference between posaconazole and voriconazole?
Conclusion: Posaconazole and voriconazole have the same prophylactic effect against IFDs in high-risk neutropenic Chinese patients. However, the safety of posaconazole is superior to that of voriconazole, while in terms of cost-effectiveness, voriconazole has an advantage over posaconazole.
Is fluconazole the same as posaconazole?
Diflucan (fluconazole) is a cheap and effective treatment for fungal infections. Noxafil (posaconazole) works against more types of fungal infections than other medications like it.
Is posaconazole FDA approved?
Posaconazole is an azole antifungal initially approved by the FDA in 2006 as an oral suspension. The delayed-release tablets and injection were approved in November 2013 and March 2014, respectively. Posaconazole’s approved dose, frequency, duration of therapy, and age range vary based on indication and formulation.
How is posaconazole administered?
Prophylaxis of invasive Aspergillus and Candida infections Loading dose: 300 mg Noxafil injection intravenously twice a day on the first day. Maintenance dose: 300 mg Noxafil injection intravenously once a day, starting on the second day. Duration of therapy is based on recovery from neutropenia or immunosuppression.
How long should you take Noxafil?
Treatment of oropharyngeal candidiasis: The usual dose for adults is 5 mL once on the first day, then 2.5 mL once a day for the next 13 days. A measuring spoon is supplied with the medicine. The dose may vary from one patient to another. Your doctor may recommend a different dose depending on your condition.
What are the indications and usage of Noxafil?
INDICATIONS AND USAGE Noxafil is an azole antifungal agent indicated for: injection, delayed-release tablets, and oral suspension •prophylaxis of invasive and
How old do you have to be to take Noxafil tablets?
Noxafil injection is indicated in patients 18 years of age and older. Noxafil delayed-release tablets and oral suspension are indicated in patients 13 years of age and older. Noxafil oral suspension is indicated for the treatment of oropharyngeal candidiasis, including oropharyngeal candidiasis refractory to itraconazole and/or fluconazole.
What happens if you take Noxafil with cyclosporine?
If you take Noxafil with cyclosporine or tacrolimus, your blood levels of cyclosporine or tacrolimus may increase. Serious side effects can happen in your kidney or brain if you have high levels of cyclosporine or tacrolimus in your blood.
Which is better Noxafil oral or delayed release tablets?
Noxafil delayed-release tablets should be used only for the prophylaxis indication. Noxafil delayed-release tablets generally provide higher plasma drug exposures than Noxafil oral suspension under both fed and fasted conditions, and therefore is the preferred oral formulation for the prophylaxis indication.