Is acarbose the same as metformin?

Is acarbose the same as metformin?

Previous randomized clinical trials demonstrated that acarbose is as effective as metformin for glycemic control (11–14). Furthermore, in the STOP-NIDDM study, acarbose treatment was shown to prevent 49% of cardiovascular events in patients with impaired glucose tolerance (IGT) (15).

Is acarbose good for diabetes?

Acarbose is not a cure for diabetes, nor is it a substitute for diet, exercise, oral hypoglycemic agents, or insulin. Adverse effects are gastrointestinal and can be diminished by starting with an initial dosage of 25 mg tid.

What is the role of acarbose?

Acarbose works by slowing the action of certain chemicals that break down food to release glucose (sugar) into your blood. Slowing food digestion helps keep blood glucose from rising very high after meals.

What type of insulin is acarbose?

No, acarbose is not a type of insulin and has no effect on the amount of insulin in your body. Instead it lowers blood sugar by slowing the amount of sugar absorbed from the food you eat.

Is acarbose better than metformin?

Metformin versus Acarbose The results showed statistically significant differences, that metformin reduced HbA1c levels by 0.38% more than acarbose (WMD, -0.38%, 95%CI, -0.736% to -0.024%; Table 2). Thus, the indirect comparison suggested that glucose lowering effect of metformin was superior to that of acarbose.

Can I take acarbose with metformin?

In combination with metformin, acarbose has been shown to improve long-term glycemic control (HbA1c measurement) by 0.8% (12), 0.65% (18), and 0.9% (19). Acarbose and metformin are both associated with beneficial effects on hyperglycemia, hyperinsulinemia, body weight, and, in some studies, triglyceride levels (20).

Is acarbose used for low blood sugar?

Acarbose lowers your blood sugar by preventing the breakdown of starch into sugar. It may be used alone or in combination with another type of oral diabetes medicine called a sulfonylurea.

Is acarbose effective?

Overall, acarbose was shown to provide significantly more weight-loss by an average of 0.52 kg (95% CI −0.78 to −0.25) as opposed to placebo (p=0.0001), and, in the Eastern population, acarbose caused significant weight loss of 1.20 kg (95% CI −1.73 to −0.68) compared with placebo (p<0.05), whereas in the Western group …

Does acarbose cause weight gain?

After 26 weeks, completed by 37 subjects in the acarbose group and by 38 subjects in the placebo group, a small weight regain of 0.6 kg was documented in the latter, whereas no weight increase was observed under acarbose treatment (p = 0.38, analysis of covariance with initial body weight as covariable).

Can you take acarbose with metformin?

Can I take acarbose after a meal?

Take acarbose at the beginning of a meal. The tablets can be chewed with your first mouthful of food, or swallowed with a drink of water. The most common side-effect is wind (flatulence). Remember to follow any advice you have been given about your diet.

What is the pkaof of acarbose 25 mg?

Acarbose is soluble in water and has a pKaof 5.1. Its empirical formula is C25H43NO18and its chemical structure is as follows: Acarbose Tablets are available as 25 mg, 50 mg and 100 mg tablets for oral use. The inactive ingredients are corn starch, magnesium stearate, microcrystalline cellulose and colloidal silicon dioxide. CLINICAL PHARMACOLOGY

What are the inactive ingredients in acarbose tablets?

Acarbose Tablets are available as 25 mg, 50 mg and 100 mg tablets for oral use. The inactive ingredients are corn starch, magnesium stearate, microcrystalline cellulose and colloidal silicon dioxide. CLINICAL PHARMACOLOGY

What is the molecular weight of acarbose tablets?

It is a white to off-white powder with a molecular weight of 645.6. Acarbose is soluble in water and has a pKa of 5.1. Its empirical formula is C 25 H 43 NO 18 and its chemical structure is as follows: Acarbose tablets are available as 25 mg, 50 mg and 100 mg tablets for oral use.

How does acarbose work for type 2 diabetes?

Acarbose is a complex oligosaccharide that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. As a consequence of plasma glucose reduction, Acarbose Tablets reduce levels of glycosylated hemoglobin in patients with type 2 diabetes mellitus.