What does E-selectin bind to?
Ligands. E-selectin recognizes and binds to sialylated carbohydrates present on the surface proteins of certain leukocytes. E-selectin ligands are expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, and natural killer cells.
Is E-selectin a receptor?
E-selectin is an adhesion receptor involved in slowing down leukocyte rolling and its expression is restricted to endothelial cells.
What is the function of selectin?
The selectins are cell surface lectins that have evolved to mediate the adhesion of white blood cells to endothelial cells and platelets under flow. They recognize fucosylated, sialylated and in some cases sulfated ligands expressed on scaffold glycoproteins serving as functional counter-receptors.
Is ICAM a selectin?
P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice.
What is soluble E-selectin?
Soluble E-selectin (sE-selectin) is shed into the circulation from the activated endothelium. We investigated the effect of sE-selectin on shear-resistant adhesion and migration of metastatic breast cancer cells and leukocytes.
What is the function of adhesion molecules?
Adhesion molecules are cell surface proteins that mediate the interaction between cells, or between cells and the extracellular matrix (ECM).
What does P-selectin bind to?
The primary ligand for P-selectin is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all leukocytes, although P-selectin also binds to heparan sulfate and fucoidans.
What type of protein is selectin?
Selectins are carbohydrate-binding transmembrane proteins expressed on platelets (P-selectins), leukocytes (L-selectins) and endothelial cells (E- and P-selectins). Their role is to mediate the first steps of the recruitment of leukocytes from the blood stream in a series of pathologic situations [51].
Where is selectin found?
endothelial cells
Selectins are a family of carbohydrate-binding transmembrane molecules found on the surface of endothelial cells, leukocytes and platelets.
Do integrins bind to Icams?
The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1 antigen, during inflammation and in immune responses.
What is the function of the Sele selectin E Gene?
SELE selectin E [ (human)] Gene ID: 6401, updated on 5-Feb-2017. The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining.
How is E-selectin expressed in endothelial cells?
E-Selectin(CD62E or previously referred to as ELAM-1) is an inducible endothelial cell surface molecule of 115 kDa. Its expression on endothelial cells is transcriptionally upregulated by various proinflammatory substances such as IL-1, TNFα and lipopolysaccharide (LPS). Cytomegalovirus infection also induces E-selectin expression.
What is the role of E selectin in breast cancer?
E-selectin-dependent rolling promotes adhesion to HA by both physically slowing cells and enabling them to position proximal to the surface, thereby increasing the on rate of adhesion. High E-selectin expression is associated with breast cancer metastasis.
Where is E-selectin found in the body?
Alberto Mantovani, Elisabetta Dejana, in Encyclopedia of Immunology (Second Edition), 1998. E-Selectin (CD62E) is a 115 kDa glycoprotein, only expressed on endothelial cells after activation by interleukin 1 (IL-1), tumor necrosis factor α (TNFα) or bacterial lipopolysaccharides.