What is a good free PSA percentage?
A cutoff of 25% or less free PSA is recommended for patients with PSA values between 4.0 and 10.0 ng/mL and a palpably benign gland, regardless of patient age or prostate size.
What if free PSA is high?
Free PSA ranges can vary, but generally, a higher ratio of free PSA to total PSA indicates a lower risk of prostate cancer. On the other hand, a low ratio of free PSA to total PSA indicates a higher risk of having prostate cancer.
What does free PSA mean in a blood test?
PSA traveling alone is called free PSA. The free-PSA test measures the percentage of unbound PSA; the PSA test measures the total of both free and bound PSA. Prostate cancer can raise PSA levels, but so can other conditions. These include an enlarged prostate, prostatitis, and advancing age.
Does BPH lower free PSA?
PSA and Free PSA were determined by ELISA using commercially available assay kits. Results: Mean PSA was found to be highest in CaP cases (41.9 +/- 38.7 ng/ml), lower in the BPH cases (13.5 +/- 10.5 ng/ml), while it was lowest in the control subjects (5.7 +/- 4.4 ng/ml).
Does BPH affect free PSA?
What is a good free PSA reading?
A PSA test measures nanograms of PSA per milliliter (ng/mL) of blood. But if you have no symptoms, the usual guidelines for total PSA levels are: Safe. Zero to 2.0 ng/mL.
Can BPH cause high free PSA?
Besides cancer, other conditions that can raise PSA levels include an enlarged prostate (also known as benign prostatic hyperplasia or BPH ) and an inflamed or infected prostate (prostatitis). Also, PSA levels normally increase with age.
What are the results of the free PSA test?
The free-PSA test measures the percentage of unbound PSA; the PSA test measures the total of both free and bound PSA. Prostate cancer can raise PSA levels, but so can other conditions. These include an enlarged prostate, prostatitis, and advancing age.
What should my free PSA level be for prostate cancer?
If your total PSA levels are in the borderline area between 4-10 ng/mL, your free PSA ratio can give you a more detailed picture of your cancer risk. The chances that a needle biopsy will turn up prostate cancer varies by your free PSA concentration and your age:
What causes low free PSA and total PSA levels?
Enlarged prostate gland. This noncancerous condition, which can make it harder for you to pee, also may drop your free PSA count. A low percentage of free PSAs to total PSAs also may be a sign that your cancer is more aggressive. Total PSA and Free PSA Levels
What are the ranges of PSA in ng / mL?
The following table shows the approximate ranges for total PSA in ng/ml by age: Age in years PSA levels in ng/ml 40–49 0–2.5 50–59 0–3.5 60–69 0–4.5 70–79 0–6.5
What does PSA percent free mean?
What is free PSA total PSA ratio?
Free and bound PSA Percent-free PSA is a ratio that compares the amount of free PSA to the total PSA level. The total PSA level includes the amount of both free and bound PSA in the blood. Free PSA levels are often higher in those with non-cancerous conditions of the prostate and lower in those with prostate cancer.
How do you calculate free PSA?
The ratio of free to total PSA is calculated by dividing free PSA by total PSA and multiplying the result by 100.
How accurate is a free PSA test?
In diagnosing carcinoma, the diagnostic accuracy of percent free PSA is 100% when tPSA is between 2.5 and 4.0 ng/ml. Percent free PSA is not linked with staging in prostatic cancer, but it does appear to be related to the Gleason score.
Is a PSA level of 25 high?
When PSA levels are: Below 4: 15% chance of prostate cancer. Between 4 and 10 (the borderline range): 25% chance of prostate cancer. Above 10: More than 50% chance of having prostate cancer.
How accurate is the free PSA test?
Can an enlarged prostate affect free PSA levels?
Age. Younger men are more likely than those over 70 to have lower free PSA counts. Enlarged prostate gland. This noncancerous condition, which can make it harder for you to pee, also may drop your free PSA count.
What does a PSA level of 20 mean?
A PSA level of less than 10 ng/mL is considered to indicate a low risk of aggressive disease. A level of 10-20 ng/mL indicates intermediate risk and a level greater than 20 ng/mL suggests a high risk of cancer progression.
What should the ratio of free PSA to total PSA be?
When the ratio of free to total PSA is between 0 and 10 percent, the risk of having cancer may be as high as 56 percent. When this ratio is greater than 25 percent, this risk reduces to 8 percent. However, these results are not conclusive evidence for or against a cancer diagnosis, and a doctor may still want to do a tissue biopsy.
Is there a cut off for the free PSA test?
William Catalona, MD, professor and chief of urology at Washington UniversitySchool of Medicine, said that the 25% cut-off for free PSA allows about95% of cancers to be detected and eliminates, on average, 20% of unnecessarybiopsies, largely in older men.
What happens if your PSA,% free result is too low?
Men with a total PSA in the same range (between 4 ng/ml and 10 ng/ml) and a free PSA below 10% need to have a biopsy. More likely than not, they have prostate cancer. What does it mean if your PSA, % Free result is too low?
What’s the difference between free PSA and bound PSA?
PSA, a protein produced by prostate gland cells, circulates through the body in two ways: either bound to other proteins or on its own. PSA traveling alone is called free PSA. The free-PSA test measures the percentage of unbound PSA; the PSA test measures the total of both free and bound PSA.