How long should you use SAM-E?
Dosing. BY MOUTH: For depression: 800-1600 mg of SAMe daily in divided doses for 4-12 weeks is most commonly used. For osteoarthritis: 600-1200 mg of SAMe daily in up to three divided doses for up to 84 days has been used.
Is Sam-E safe to take long term?
Information on the long-term safety of SAMe is limited because the participants in most studies took it only for short periods of time. However, in one study of alcohol-related liver disease, participants took SAMe for 2 years; in that study, no serious side effects were reported.
Can you just stop taking Sam-E?
Any time you are taking anything for your mood whether it is a prescribed antidepressant or a supplement such as SAMe, you need to taper off from it should you decide to quit taking it. I had such an abrupt mood change that I was left spiraling out of control and ended up having to call a suicide hotline.
How many mg of Sam-E should I take?
How much SAM-e should you take? There is no established ideal dose of SAM-e. For depression, many studies have started patients at 400 to 600 milligrams daily. For osteoarthritis, 600-1,200 milligrams daily of SAM-e divided into three doses is common.
Is SAMe good for anxiety?
SAMe is used by mouth for depression, anxiety, heart disease, fibromyalgia, abdominal pain, osteoarthritis, bursitis, tendonitis, chronic lower back pain, dementia, Alzheimer’s disease, slowing the aging process, chronic fatigue syndrome (CFS), improving mental performance, liver disease, and Parkinson’s disease.
Is SAM-e safe for kidneys?
The established nephroprotective properties of SAM that are potentiated by Meldonium are probably due to the ability of these drugs to eliminate endothelial dysfunction, improve microcirculation, and prevent the progression of kidney fibrosis.
Is 400 mg of SAMe enough?
He recommended a daily dose of 400 mg for mild depression. “Keep in mind that absorption is better on an empty stomach,” he said. “Starting patients with 200 mg 30 minutes before breakfast and 30 minutes before lunch minimizes the overstimulation and insomnia which some patients report in the first few weeks.
How long does SAMe take to work?
In contrast, SAMe has a relatively rapid onset of action, usually within one week of starting treatment. Another important advantage of SAMe is the absence of clinically significant interactions with prescription medications and relatively few side effects compared to antidepressants.
Can SAMe make anxiety worse?
“The most common side effect of SAMe is nausea and, less frequently, diarrhea, abdominal discomfort, or vomiting. Occasionally agitation, anxiety, or insomnia can occur in patients sensitive to activating effects of SAMe.