What is adenovirus serotype?
Human species C adenovirus serotype 5 (Ad5) is the most common viral vector used in clinical studies worldwide. Ad5 vectors infect liver cells in vivo with high efficiency via a poorly defined mechanism, which involves virus binding to vitamin K-dependent blood coagulation factors.
Are there different types of adenovirus?
More than 100 serologically distinct types of adenovirus have been identified, including 49 types that infect humans. The family Adenoviridae is divided into two Genera, the mammalian adenoviruses (mastadenoviruses) and the avian adenoviruses (aviadenoviruses).
How many adenovirus serotypes are there?
They have a broad range of vertebrate hosts; in humans, more than 50 distinct adenoviral serotypes have been found to cause a wide range of illnesses, from mild respiratory infections in young children (known as the common cold) to life-threatening multi-organ disease in people with a weakened immune system.
Is adenovirus life threatening?
Symptoms are usually mild in relatively healthy people, but adenovirus in children or the elderly can be quite severe, even deadly.
What is serotype in virus?
A serotype or serovar is a distinct variation within a species of bacteria or virus or among immune cells of different individuals. These microorganisms, viruses, or cells are classified together based on their surface antigens, allowing the epidemiologic classification of organisms to the subspecies level.
Which type of virus has single serotype worldwide?
Dengue virus (DENV) is the cause of dengue fever. It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus….
| Dengue virus | |
|---|---|
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Kitrinoviricota |
What organs does an adenovirus infect?
The two most common organ systems affected by adenovirus are the respiratory and gastrointestinal (GI) tracts. Infections can appear as a “common cold” upper respiratory infection. One can also develop a lower respiratory infection such as bronchitis or pneumonia.
What family does adenovirus belong to?
Adenoviruses belong to the family Adenoviridae. There are four genera: Mastadenovirus, Aviadenovirus, Atadenovirus and Siadenovirus. At present 51 antigenic types of human adenoviruses have been described.
How long is someone contagious with adenovirus?
Ad14 is contagious and is transmitted person to person and by touching contaminated surfaces. The incubation period averages about five to eight days, but the contagious period can last for weeks to months. Risk factors include crowded living conditions, contact with an infected individual, and immunosuppression.
How long does adenovirus stay in the body?
Adenoviruses most often infect the airways leading to cold-like symptoms, including sore throat, sneezing, runny nose, cough, headache, chills, or symptoms of croup or bronchitis. Some people might also get a fever. Illness usually lasts three to five days, but serious infections can last for weeks.
What is the survival rate of adenovirus?
In immunocompromised patients, adenovirus can be acquired not only by person-to-person transmission but also from reactivation, to produce a wide variety of syndromes, including gastroenteritis, hepatitis, and hemorrhagic cystitis (in addition to pneumonia), with mortality rates ranging from 38-100% and with a …
Can babies get adenovirus?
Adenovirus infections can affect children of any age. But they’re more common in babies and young children. Most kids have had at least one adenovirus infection before age 10.
Is Ad26 a human virus?
Human Ad26 has been considered to be a low-prevalent adenovirus due to the low frequency of Ad26 neutralizing antibodies in various populations compared with human adenovirus type 5.
What is a viral serotype?
Can adenovirus affect the brain?
Adenovirus gene transfer causes inflammation in the brain.
How long can adenovirus live outside the body?
SURVIVAL OUTSIDE HOST: Most serotypes are stable at 36 °C for a week, for several weeks at room temperature, and for several months at 4 °C(1,8). Adenoviruses are very stable in the environment and persist for 7 days to 3 months on dry inanimate surfaces(8).
What other vaccines use Ad26?
The following vaccine candidates have been evaluated in clinical programs:
- Ad26. ZEBOV for Ebola virus.
- Ad26. Mos. HIV, Ad26. Mos4. HIV, and Ad26. ENVA. 01 for HIV.
- Ad26. CS. 01 for Malaria.
- Ad26. RSV. FA2 and Ad26. RSV. preF for RSV.
- Ad26. Filo for Filovirus.
- Ad26. ZIKV. 001 for Zika.
- Ad26. HPV16 and Ad26. HPV18 for HPV.