How does mTOR activate S6K?
S6K and 4EBP regulate translational initiation and control protein synthesis. Activation of S6K by mTOR is followed by phosphorylation of a downstream ribosomal protein, S6, at serine 235/236, an alternative marker for mTOR activity, to promote protein translation (Fingar et al., 2004; Hay and Sonenberg, 2004).
What phosphorylates S6K?
S6K protein was phosphorylated by JNK1 at S411 and S424 in the carboxyl terminal autoinhibitory domain. The phosphorylation was observed in kinase assay with purified S6K as a substrate, and in cells after JNK1 activation by TNF-α or MEKK1 expression.
How does mTOR inhibit autophagy?
mTORC1 tightly regulates autophagy by suppressing autophagy induction via phosphorylation-dependent inhibition of ULK1/2 and the VPS34 complex and by preventing global expression of lysosomal and autophagy genes through TFEB phosphorylation.
Does mTOR activate Akt?
The serine/threonine kinase Akt is an upstream positive regulator of the mammalian target of rapamycin (mTOR). The known pathway by which Akt activates mTOR is via direct phosphorylation and inhibition of tuberous sclerosis complex 2 (TSC2), which is a negative regulator of mTOR.
Where can I find information about General Dynamics?
Employee Self Service. Current employees can update and access many employment details from the General Dynamics Employee Self-Service website, ess.gendyn.com, or by calling 877-GD-EMP-SRV (1-877-433-6777).
What is the stock price of General Dynamics?
GD (NYSE) $189.96 September 13, 2019 04:02PM. General Dynamics is a global aerospace and defense company. From Gulfstream business jets and combat vehicles to nuclear-powered submarines and communications systems, people around the world depend on our products and services for their safety and security.
How to contact General Dynamics mission systems employees?
Current employees can update and access many employment details from the General Dynamics Employee Self-Service website or by calling 877-GD-EMP-SRV (1-877-433-6777). Mission Systems’ Wellness Program: Be Well Be Dynamic provides free biometric screenings and flu shots with incentives for healthy behaviors.
When is the Skyway 10K for General Dynamics?
Annual Skyway 10K Run Benefits the Armed Forces Families Foundation (AFFF) On March 3rd 2019, General Dynamics Ordnance and Tactical Systems employees participated in the 2nd Annual Skyway 10K benefiting the Armed Forces Families Foundation (AFFF).