What is van der knaap disease?
Van der Knaap disease or megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare, inherited, autosomal recessive disorder. It is characterised by macrocephaly and slowly progressive ataxia, spasticity, and cognitive decline. The usual age of onset is described from birth to infancy.
What causes MLC?
For the classic disease type, MLC is caused by two mutations in either the MLC1 gene or the GLIALCAM gene. The improving disease type, meanwhile, is caused by one mutation in the GLIALCAM gene. Both genes (MLC1 and GLIALCAM) affect the production of the MLC1 protein which helps to regulate the volume of the brain.
What is an mlc in radiology?
Megalencephalic leukoencephalopathy with subcortical cysts (MLC)
What does MCL stand for?
The medial collateral ligament (MCL) is one of the ligaments in the knee joint.
How long does MCL take to heal?
Recovery time for an MCL injury depends on the severity of the damage. On average, these injuries take six weeks to heal. No matter the grade of the tear, initial treatment focuses on immobilizing the knee and reducing pain and inflammation.
What MLC medical?
MEDICO-LEGAL CASE {MLC} a. Definition of Medico-legal Case. Cases wherever attending doctor after taking history and clinical examination of the patient thinks that some investigation by law enforcing agencies are essential so as to fix the responsibility regarding the case in accordance with the law of land.
What MLC means?
Qualification and Tenure To become a member of a State Legislative Council (MLC), a person must be a citizen of India, at least 30 years old, mentally sound, not an insolvent, and must be enrolled on the voters’ list of the state for which he or she is contesting an election.
Is there a cure for Megalencephalic leukoencephalopathy?
There is currently no cure for this disease. Treatment for MLC is directed at the symptoms as they arise, for instance anti-epileptic drugs to treat seizures, and is largely supportive. How is research on MLC progressing towards better treatments?
What is megalencephalic leukoencephalopathy with subcortical cysts ( MLC )?
What is Megalencephalic Leukoencephalopathy with subcortical Cysts (MLC)? Megalencephalic Leukoencephalopathy with subcortical Cysts (MLC) is a genetic disorder that affects the nervous system and causes neurologic symptoms. It usually affects children in the first year of life.
Where does the name megalencephalic leukoencephalopathy come from?
Megalencephalic leukoencephalopathy with subcortical cysts (MLC1) is a very rare disorder affecting the ‘white matter’ of the brain, often leading to progressive loss of physical, and sometimes mental, skills over very many years. The name comes from the Greek and describes the features of the condition.