Why is it important to study teratogens?
Geneticists specialize in the effects of teratogens on fetuses and can help you assess your actual risk given a specific exposure. You may also receive a targeted ultrasound evaluation to determine whether the fetus has been affected in some way.
What is teratogenicity in pregnancy?
A teratogen (ter-AT-uh-jen) is something that can cause or raise the risk for a birth defect in a baby. They are things that a mother may be exposed to during her pregnancy. Teratogens include: Some medicines.
What is teratogen used for?
Teratogenic drugs: A teratogen is an agent that can disturb the development of the embryo or fetus. Teratogens halt the pregnancy or produce a congenital malformation (a birth defect).
What does teratogenic effect mean?
Teratogenic drugs: A teratogen is an agent that can disturb the development of the embryo or fetus. Teratogens halt the pregnancy or produce a congenital malformation (a birth defect). Classes of teratogens include radiation, maternal infections, chemicals, and drugs.
What is teratogenicity in pharmacology?
Teratogenicity is the ability of a drug to cause fetal abnormalities or deformities.
What is teratogenic medication?
Drugs that can cause birth defects are said to be ‘teratogenic drugs’. Medical science cannot always predict how exposure to a teratogenic drug will affect a developing fetus. It can be dangerous for a pregnant woman to stop taking prescription drugs if she has a medical condition or becomes ill.
Which drug causes teratogenicity?
Teratogenic drugs and birth defects
- ACE (angiotensin converting enzyme) inhibitors.
- angiotensin II antagonist.
- isotretinoin (an acne drug)
- alcohol.
- cocaine.
- high doses of vitamin A.
- lithium.
- male hormones.
What is teratogenicity Slideshare?
Teratogenicity • It refers to capacity of a exogenous agents to cause foetal abnormalities when administered to the mother at any stage of pregnancy. • The placenta does not strictly constitute a barrier and any drug can cross it to a greater or lesser extent.
What is the embryo period?
After conception, your baby begins a period of dramatic change known as the embryonic stage. This stage runs from the 5th through the 10th week of pregnancy. During this stage, the baby is called an embryo.
What is a teratogenic drug?
What does teratogenicity stand for in medical terms?
2. Teratogenicity is the ability to cause developmental abnormalities in the foetus. Congenital malformations:- non reversible functional or morphological defects present at birth Teratology (teras- monster, logos study of) is the study of abnormalities of physiological development.
What are some of the mechanisms of teratogenicity?
TERATOGENIC MECHANISMS: • Folate antagonism • Neural crest cell disruption • Endocrine disruption • Oxidative stress • Vascular disruption and specific receptor • Enzyme-mediated teratogenesis 11.
Are there any studies on teratogenicity in rats?
A teratogenicity study was conducted in which groups of 25–27 female rats were bred and given daily doses of 100, 300, or 700 mg OPP kg−1 bw by gavage on days 6–15 of gestation. No evidence of maternal or fetal toxicity was produced by administration of the two lower dose levels.
Is there a maximum risk of teratogenicity?
Teratogenic risk is at a maximum during this short period. The occurrence of a malformation depends on the drug, the genetic background of each embryo, and the moment of exposure during the organogenesis timeline.