What is ursolic acid used for?
Ursolic acid added to feed increased murine skeletal muscle mass, fast and slow muscle fiber size, grip strength, and exercise capacity. Interestingly, ursolic acid increased energy expenditure, leading to reduced obesity, improved glucose tolerance, and decreased hepatic steatosis.
Is ursolic acid safe?
Ursolic acid consumed in the diet is safe. No large, long-term, randomized controlled clinical trials have tested ursolic acid supplements, and therefore, long-term safety for supplements is unknown. Drug interactions with ursolic acid are also not known.
What is another name for oleanolic acid?
Oleanic acid
Oleanolic acid
| Names | |
|---|---|
| Other names Oleanic acid | |
| Identifiers | |
| CAS Number | 508-02-1 |
| 3D model (JSmol) | Interactive image |
Is ursolic acid a polyphenol?
A number of polyphenols have been identified, including ursolic acid, benzoic acid and derivatives, quercitin and hydroxyl flavonol glycosides, such as quercitin glucoside and galactoside.
Is ursolic acid anabolic?
In mice fed a high fat diet, ursolic acid increases skeletal muscle Akt signaling, anabolic mRNA expression, grip strength, skeletal muscle mass, and fast and slow skeletal muscle fiber size.
Does cranberry juice contain ursolic acid?
Cranberry triterpenoids: properties of ursolic acid and its phenolic esters. The peel of cranberry fruit contains a substantial amount of pentacyclic triterpenoid ursolic acid. None was detected in commercial cranberry juice.
Does ursolic acid increase testosterone?
BPH-induced animals displayed an increase in prostate weight with increased testosterone and DHT levels in both the serum and prostate. However, ursolic acid treatment resulted in significant reductions in prostate weight and testosterone and DHT levels in both the serum and prostate, compared with BPH-induced animals.
Is oleanolic acid good?
Oleanolic acid had beneficial effects in clinical trials on chronic kidney disease, diabetes mellitus type 2, and some inflammatory conditions such as arthritis. There are about 500 registered clinical trials regarding the therapeutic effects of olive.
What foods contain oleanolic acid?
The most important sources of oleanolic acid in human diet are olives (Olea europaea L.), from which the compound derives its name, and their products, such as olive oil [27]. It is estimated that in the Mediterranean diet, containing olives and olive oils, total daily intake of oleanolic acid is around 25 mg [28].
Are triterpenoids polyphenols?
Regarding chemical composition, chlorogenic acid, quinic acid and arbutin were the primary polyphenols and ursolic acid was the predominant triterpenoid, whereas 27 polyphenolic compounds, especially chlorogenic acid and most of the flavan-3-ols, were the main antioxidants in young pears.
Does ursolic acid help build muscle?
As a result, ursolic acid increased skeletal muscle mass, fast and slow muscle fiber size, grip strength and exercise capacity. Interestingly, ursolic acid also increased brown fat, a tissue that shares developmental origins with skeletal muscle.
How much ursolic acid is in apple peel?
It has been found that apple peel contains about 50 mg of this acid per medium sized apple with a surface area of 50-70 cm 2 [81, 82] . …
How is ursolic acid used in the treatment of cancer?
Ursolic acid is a naturally synthesized pentacyclic triterpenoid, widely distributed in different fruits and vegetables. Current research suggested that ursolic acid and its derivatives exhibited anticancer activity, anti-inflammatory effects, and induction of apoptosis in several human cancer cells.
Are there any health benefits to ursolic acid?
A number of potential biochemical effects of ursolic acid have been investigated, but there has been no clinical study demonstrating benefits to human health.
What kind of plants have ursolic acid in them?
Ursolic acid is present in many plants, such as Mirabilis jalapa, as well as in many fruits and herbs used in daily life (e.g. apples, basil, bilberries, cranberries, elder flower, peppermint, rosemary, lavender, oregano, thyme, hawthorn, and prunes).
What does ursolic acid do to the brain?
Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. Ursolic acid enhances mouse liver regeneration after partial hepatectomy. Ursolic acid enhances the cellular immune system and pancreatic beta-cell function in streptozotocin -induced diabetic mice fed a high-fat diet.