What happens if you drink too much grapefruit juice?
Eating a grapefruit or consuming its juices while taking certain medications could lead to gastrointestinal bleeding, kidney failure, depressed breathing and sudden death, warns a new paper in the Canadian Medical Association Journal.
What is the danger associated with drinking grapefruit juice while taking some medications?
The bottom line Grapefruit interferes with proteins in the small intestine and liver that normally break down many medications. Eating grapefruit or drinking grapefruit juice while taking these medications can lead to higher levels of them in your blood — and more side effects.
What medications should not be taken with fruit juice?
Fruit Juices Block Common Drugs
- The allergy drug Allegra, available generically as fexofenadine.
- The antibiotics ciprofloxacin (Cipro, Proquin), levofloxacin (Levaquin), and itraconazole (Sporanox)
- The beta-blocker blood pressure drugs atenolol (Tenormin), celiprolol, and talinolol.
What does inhibition by grapefruit juice cause?
The hepatic enzyme inhibition may cause an additional increase in potency and a prolonged metabolic half-life (prolonged metabolic half-life for all ways of drug administration). The degree of the effect varies widely between individuals and between samples of juice, and therefore cannot be accounted for a priori.
Is grapefruit juice bad for kidneys?
Grapefruits are great fruits: Citrus juice could keep your kidneys healthy, according to a new study from the U.K. Researchers discovered that a flavonoid called naringenin—found in grapefruit, oranges, and tomatoes—regulates a protein that decreases growths related to kidney cysts, which can lead to kidney failure.
What are side effects of drinking too much water?
The symptoms of overhydration can look like those of dehydration. When you have too much water in the body, the kidneys can’t remove the excess liquid. It starts collecting in the body, leading to nausea, vomiting, and diarrhea. Throbbing headaches all through the day.
How much grapefruit juice causes a drug interaction?
One whole grapefruit or 200 mL of grapefruit juice is sufficient to cause clinically relevant increased systemic drug concentration and subsequent adverse effects. Seville oranges, (often used in marmalades), limes and pomelos also produce this interaction.
How does grapefruit juice affect calcium channel blockers?
Grapefruit juice interacts with some calcium channel blockers and increases the level of the medicine in your blood. If you’re taking any of the medicines below, seek advice from your pharmacist or doctor if you wish to include grapefruit or grapefruit juice in your diet.
Why does grapefruit juice interact with medications?
Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine. Grapefruit juice can block the action of intestinal CYP3A4, so instead of being metabolized, more of the drug enters the blood and stays in the body longer. The result: too much drug in your body.
What medication can’t you have grapefruit with?
Examples of common medications that interact with grapefruit juice include certain statin cholesterol drugs such as atorvastatin (Lipitor), lovastatin, simvastatin (Zocor), felodipine (Plendil) and other calcium channel blockers, clarithromycin (Biaxin), and loratadine (Claritin).
What happens if you drink grapefruit juice everyday?
Regularly consuming grapefruit is thought to improve heart health by reducing risk factors for heart disease, such as high blood pressure and cholesterol. In one study, people who ate grapefruit three times daily for six weeks experienced significant reductions in blood pressure over the course of the study.
Is grapefruit hard on kidneys?
How does grapefruit juice affect your drug intake?
Grapefruit juice affects how drugs are changed (metabolized) in the body for eventual elimination, and can alter the amount of drug in your blood. Grapefruit juice drug interactions can be researched with the Drugs.com Interaction Checker.
How are Statins broken down in grapefruit juice?
A: Certain classes of drugs — most notably statins — are metabolized (broken down) in your intestines by an enzyme called CYP3A, which normally reduces the amount of drug that enters your bloodstream. Grapefruit juice contains compounds called furanocoumarins that stop CYP3A from doing its job.
Is it safe to drink half a grapefruit?
What’s more, eating half a grapefruit is even less risky than drinking grapefruit juice, since it takes several fruits to make a single glass of juice. But to be on the safe side, check with your doctor, and avoid taking your pills with grapefruit juice. Grapefruit juice affects certain statins more than others.
Are there any over the counter interactions with grapefruit juice?
Grapefruit juice interactions can even occur with over-the-counter (OTC) drugs. But why is this so important? Interactions with grapefruit can occur with common and important medications – such as those that lower cholesterol, treat high blood pressure, or even those that fight cancer.