What is the pH of loratadine?

What is the pH of loratadine?

Acidity constant of loratadine was found to be pK(a) 5.25 and those of desloratadine pK(a1) 4.41 and pK(a2) 9.97.

What is the pH of fexofenadine?

pH: The pH of a 1 mg/mL solution of fexofenadine HCl is 3.618. Each ALLEGRA 12 Hour tablet contains 60 mg fexofenadine hydrochloride.

What is the difference between loratadine and fexofenadine?

In this study, fexofenadine HCl was significantly more effective than loratadine in relieving eye symptoms and nasal congestion. Furthermore, fexofenadine was significantly better than loratadine in improving QoL.

Is fexofenadine more effective than loratadine?

Results: Mean decreases in TSS were significantly greater with loratadine than with fexofenadine for the 659 patients who completed phase 1 (-12.7 vs -10.2, respectively; P = 0.019; patient assessment) and for the 389 patients who responded to initial therapy (-6.6 vs -6.1, respectively; P = 0.037; investigator …

Is loratadine acidic or alkaline?

Acidity constant of loratadine was found to be pKa 5.25 and those of desloratadine pKa1 4.41 and pKa2 9.97.

Is loratadine water soluble?

Graphical abstract. Loratadine is a drug used to treat allergy, however its low water solubility limits the bioavalability.

Is fexofenadine water soluble?

Fexofenadine hydrochloride is a white to off-white crystalline powder. It is freely soluble in methanol and ethanol, slightly soluble in chloroform and water, and insoluble in hexane.

Is fexofenadine the same as fexofenadine hydrochloride?

Allegra (What is Allegra?) is the brand name for fexofenadine hydrochloride. It is available in different dosage forms such as an oral tablet, oral capsule, orally disintegrating tablet (ODT), and oral suspension.

Can you take loratadine and fexofenadine at the same time?

Different oral antihistamines such as diphenhydramine, cetirizine, loratadine, levocetirizine, desloratadine, and fexofenadine should never be taken together. Taking different oral antihistamines together can lead to an antihistamine overdose.

Can I take both loratadine and fexofenadine together?

Can I take loratadine and fexofenadine together?

No interactions were found between fexofenadine and loratadine. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

What’s the difference between loratadine and fexofenadine?

Compared with fexofenadine, loratadine demonstrated a statistically greater percentage reduction in am and pm reflective TSS in four of the initial five assessments (p < 0.05 for day 1 pm, day 2 pm, and day 3 am and pm assessments), achieving significance versus fexofenadine as early as 12 hours following the first dose (day 1 pm).

Which is better, fexofenadine or ioratadine for rhinitis?

Overall, ioratadine provided significantly better therapeutic response than fexofenadine in patients who failed to respond to initial therapy with the other drug. Efficacy and tolerability of loratadine versus fexofenadine in the treatment of seasonal allergic rhinitis: a double-blind comparison with crossover treatment of nonresponders

What’s the difference between Allegra and fexofenadine?

Allegra is also a brand name, and fexofenadine is the generic name and active ingredient. Fexofenadine has not been available over the counter as long as loratadine. It became over the counter in 2011. Allegra doses are available in 30, 60, and 180 mg.

Where does fexofenadine compete with H1 histamine receptors?

Fexofenadine is a highly selective and reversible competitor at peripheral H1 histamine receptors in the gastrointestinal (GI) tract, blood vessels, and bronchial smooth muscle.